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unreviewed

Adenine phosphoribosyltransferase (APRT)

1 reactions · 1 pathways

Cofactors used

PPi PRPP

What it does, reaction by reaction

1 reactions

Purine Salvage Pathway Nucleotide Metabolism · Cytosol

step 3 Irreversible

Adenine → AMP

Converts Adenine into AMP

› Notes

Adenine phosphoribosyltransferase (APRT) catalyzes adenine + PRPP → AMP + PPi. The reaction uses PRPP and Mg2+ and is effectively irreversible because cellular pyrophosphatases hydrolyze PPi.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Strategies and applications for alleviating carbon catabolite repression.

    Lu M, Ding H, Zhang H, Xu J, Meng R, Li Y, Zhang Z, Zheng P, Zhu Y, Sun J. · 2026-08-20

    open access unreviewed
  2. 2
    Development of a qualitative detection method for the pSIM1278 construct in genetically modified potato using real-time PCR.

    Sugino M, Soga K, Narushima J, Matsumoto M, Takabatake R, Yoshiba S, Shibata N. · 2026-04-24

    open access unreviewed
  3. 3
    Nutritional supplements to improve esports player performance: a systematic review of randomized controlled trials.

    Huang D, Zheng Y, Xu M, Huang W. · 2025-12-22

    cited 2× open access unreviewed
  4. 4
    Renal atrophy and acute contralateral obstructive uropathy secondary to 2,8-dihydroxyadenine nephropathy: A case report based discussion on diagnostic pitfalls, FTIR spectroscopy, and literature review.

    Agrawal V. · 2026-09-10

    open access unreviewed
  5. 5
    Adenine phosphoribosyltransferase deficiency and 2,8-dihydroxyadeninuria.

    Edvardsson VO, Runolfsdottir HL, Palsson R. · 2026-03-13

    cited 1× open access unreviewed
  6. 6
    Mesenchymal stem cell-derived extracellular vesicle treatment of induced pluripotent stem cell-derived motor neurons with different amyotrophic lateral sclerosis genetic backgrounds.

    Varderidou-Minasian S, Jakobs CE, Pasteuning-Vuhman S, Gal L, Timmers A, Altelaar M, Lorenowicz MJ, Pasterkam… · 2026-02-05

    open access unreviewed
  7. 7
    Automated GenePy gene-burden computation via a reproducible Nextflow workflow integrated with the Genomics England (GEL) Lifebit platform

    · 2026-09-28

    open access unreviewed
  8. 8
    Shenghui decoction improves sleep-deprivation-induced cognitive impairment in mice by modulating neuroinflammation, NRG1/ErbB4 signaling, and purine metabolism.

    Lei Y, Tan J, Zhang M, Zhang S, Xia J, Yin C, You Q. · 2026-09-28

    unreviewed
  9. 9
    Increased Risk of Gout among Patients with Trisomy 21: Insights from a Population-Based Study of over 30,000 Patients with Trisomy 21.

    Abdelmaksoud A, Igoe A, AbdAlnaeem MA, Toraih EA, Roller BA, Kaelber KL, Kaelber DC. · 2026-06-16

    open access unreviewed
  10. 10
    The Discovery of GSK3227634: A Potent Inhaled Inhibitor of the KEAP1/NRF2 Protein-Protein Interaction for the Treatment of Chronic Obstructive Pulmonary Disease.

    Callahan JF, Davies TG, Bantscheff M, Bedard S, Boehm J, Booth-Genthe C, Concha N, Copley R, Davis A, Davis R… · 2026-09-01

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.