gamma-Glutamylcysteine synthetase (GCL)
Cofactors used
Clinical / pharmacological. Rate-limiting for glutathione synthesis; feedback-inhibited by GSH
What it does, reaction by reaction
Glutathione Metabolism (gamma-Glutamyl Cycle) Amino Acid & Nitrogen Metabolism · Cytosol
L-Glutamate + L-cysteine + ATP -> gamma-glutamylcysteine + ADP + Pi
Converts Glutamate Cysteine ATP into gamma-Glutamylcysteine ADP Pi
› Notes
Rate-limiting step; feedback-inhibited by GSH. Cysteine availability is usually the limiting substrate.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.
Zhang JY, Yang YQ, Zhang ZX, Jin JL, Luo ZY, Wang DY, Ruan CX, Dai TZ, Huang YL, Xu J, Shi JW, Li JY, Lei PF. · 2026-09-03
open access unreviewed -
2
Key molecular networks underlying retinol's biphasic effects on cell proliferation through multi-omics integrative analysis using genome-scale metabolic modeling.
He P, Xiang G, Yan Y, Zhong J, Liang Y, Shu P, Lu H. · 2026-06-19
open access unreviewed -
3
Ferroptosis in major depressive disorder: Molecular mechanisms, cellular vulnerability, and therapeutic opportunities.
Kong D, Duan R, Wang X, Wang X, Zhao J. · 2026-09-18
open access unreviewed -
4
The noncoding RNA GRAS1 interacts with NKAP and protects against DNA damage and cell death.
Su T, Trang N, Kong L, Cheung D, Zhu J, Chou V, Ellis L, Camden N, Huang C, McHugh CA. · 2026-09-30
open access unreviewed -
5
Dietary α-Mangostin alleviates lipopolysaccharide-induced stress and enhances growth performance in broilers via improved intestinal immunity and integrity.
Fu K, Yue Y, Zhao J, Li X, Zhang B. · 2026-08-12
open access unreviewed -
6
Natural products alleviate exercise-induced fatigue by modulating gut microbiota: a systematic review.
Yan D, Jiao T. · 2026-09-07
open access unreviewed -
7
Network pharmacology combined with the experiments reveals ferroptosis-related targets of quercetin against DON-induced liver injury.
Zhu K, Wang P, Song C, Liu A. · 2026-08-25
unreviewed -
8
Ferroptosis: significance to zoonotic diseases and therapeutic prospects.
Tian L, Cheng X, Ni J, Yang R, Ouyang W, Qi T, Liu Q, Wang D, Chen H, Wang X. · 2026-08-25
open access unreviewed -
9
Integrated transcriptomic and metabolomic analyses provide new insights into the response of black rockfish (Sebastes schlegelii) larvae to temperature fluctuations.
Huang Y, Wang F, Jin H, Liu Q, Li J, Shen P, Lin A, Xiong Y, Yan H, Liu Q, Ma H. · 2026-08-14
unreviewed -
10
<i>Phocaeicola coprocola</i> attenuates liver fibrosis by modulating extracellular matrix remodeling.
Lee KJ, Park JH, Park H, Kim MJ, Yoon H, Kim JM, Han SH, Suk KT. · 2026-08-17
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.