What it does, reaction by reaction
Oxidative Phosphorylation (Chemiosmotic Mechanism and ATP Synthase) Energy Metabolism & Cellular Respiration · Inner mitochondrial membrane
ATP export and phosphate import: ATPmatrix + ADPcytosol ⇌ ATPcytosol + ADPmatrix; H2PO4−cytosol + H+intermembrane space → H2PO4−matrix + H+matrix
Converts ATP (matrix) ADP (cytosol) into ATP (cytosol) ADP (matrix) Pi (cytosol) H+ (intermembrane space)
› Notes
Required substrates: ADP, ATP, Pi, and the electrochemical gradient. These transport steps are essential to effective oxidative phosphorylation and are included when estimating the practical ATP cost per cytosolic ATP delivered.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Oxidative Phosphorylation (Chemiosmotic Mechanism and ATP Synthase)
Listed there as: Adenine nucleotide translocase (ANT)
Cytosolic ADP, matrix ATP, membrane potential
Atractyloside/carboxyatractyloside; bongkrekic acid
Indirect modulation through cellular ATP demand and mitochondrial content
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Lactylation landscape of mitochondrial proteins in myocardial infarction.
Kadam A, Kashyap S, Samantaray K, Jaiswal N, Goyani S, Kramer PA, Hadi P, Lee J, Furdui CM, Jadiya P, Tomar D. · 2026-05-18
open access unreviewed -
2
Single cell and spatial transcriptomic profiling of the type 2 diabetic coronary microcirculation and myocardium.
McCallinhart PE, Strawser CH, Garfinkle EAR, Navarro JB, McAllister C, Vetter TA, Lucchesi PA, Mardis ER, Mez… · 2025-11-07
cited 1× open access unreviewed -
3
Senolysis by GLS1 Inhibition Ameliorates Kidney Aging by Inducing Excessive mPTP Opening Through MFN1.
Chen Y, Zhao N, Zhang Y, Chen X, Chen Y, Wang Y, Wu J, Zhao W. · 2025-03-01
cited 6× open access unreviewed -
4
Regulated cell death in chronic kidney disease: current evidence and future clinical perspectives.
Giuliani KTK, Adams BC, Healy HG, Kassianos AJ. · 2024-10-31
cited 1× open access unreviewed -
5
Cyclophilin D participates in the inhibitory effect of high-fat diet on the expression of steroidogenic acute regulatory protein.
Su X, Lin D, Luo D, Sun M, Wang X, Ye J, Zhang M, Zhang Y, Xu X, Yu C, Guan Q. · 2019-08-01
cited 13× open access unreviewed -
6
The novel cyclophilin-D-interacting protein FASTKD1 protects cells against oxidative stress-induced cell death.
Marshall KD, Klutho PJ, Song L, Krenz M, Baines CP. · 2019-07-03
cited 7× unreviewed -
7
Physical Activity Associated Proteomics of Skeletal Muscle: Being Physically Active in Daily Life May Protect Skeletal Muscle From Aging.
Ubaida-Mohien C, Gonzalez-Freire M, Lyashkov A, Moaddel R, Chia CW, Simonsick EM, Sen R, Ferrucci L. · 2019-03-26
cited 91× open access unreviewed -
8
Running-wheel activity delays mitochondrial respiratory flux decline in aging mouse muscle via a post-transcriptional mechanism.
Stolle S, Ciapaite J, Reijne AC, Talarovicova A, Wolters JC, Aguirre-Gamboa R, van der Vlies P, de Lange K, N… · 2017-11-09
cited 26× open access unreviewed -
9
Cyclophilin D regulates the dynamic assembly of mitochondrial ATP synthase into synthasomes.
Beutner G, Alanzalon RE, Porter GA. · 2017-11-03
cited 70× open access unreviewed -
10
Combined defects in oxidative phosphorylation and fatty acid β-oxidation in mitochondrial disease.
Nsiah-Sefaa A, McKenzie M. · 2016-02-02
cited 111× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.