What it does, reaction by reaction
Deoxyribonucleotide Formation (Ribonucleotide Reductase pathway and thymidylate synthesis) Nucleotide Metabolism · Cytosol
dCMP → dUMP
› Notes
dCMP deaminase catalyzes dCMP + H2O → dUMP + NH3. The enzyme provides a second dUMP source and uses allosteric control to coordinate dCTP and dTTP pools; dCTP generally activates and dTTP inhibits the enzyme.
Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)
dCMP → dUMP (alternative route)
› Notes
dCMP deaminase catalyzes dCMP + H2O → dUMP + NH3. This allosterically regulated reaction provides another major dUMP source and contributes to balanced dCTP/dTTP pools.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Deoxyribonucleotide Formation (Ribonucleotide Reductase pathway and thymidylate synthesis)
dCTP (allosteric activation)
dTTP (allosteric inhibition)
Cell-cycle-linked expression; no major direct endocrine allostery.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Multimodal deep learning for predicting WHO/ISUP grading in renal tumors on CT using a self-attention-based model: variable Vision Transformer (vViT).
Usuzaki T, Matsuno E, Shizukuishi T, Inamori R, Zeng Y, Zhang X, Oguro S, Homma N, Takase K. · 2026-07-04
open access unreviewed -
2
Genomic and Phenotypic Characterization of Two Novel Enterobacter Phages With EDTA-Enhanced Antibiofilm Activity.
Haq K, Newland-Smith Z, Figgit M, Lee D, Duedu K. · 2026-10-01
open access unreviewed -
3
TRPM4 Expression as a Predictive Biomarker and a Mechanistic Driver of Acetalax Activity in Prostate Cancer: Preclinical Efficacy Studies.
Hoshi-Kadonosawa Y, Reinhold WC, Taniyama D, Inoue Y, Luna A, Kumar S, Sun NY, Kim YS, Yin JJ, Roper N, Sowal… · 2026-10-01
unreviewed -
4
Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation.
Fisher IJ, Senarath K, Outlaw K, Muralidharan K, Garland-Kuntz EE, Van Camp MM, Komay T, Laskowski LF, Inoue … · 2026-09-30
open access unreviewed -
5
The protein kinase IKK epsilon shapes the melanoma tumor microenvironment by modulating angiogenesis and the T-cell immunity.
Haß M, Mungo E, Benning D, Weigert A, Aliraj B, Jakob J, Häupl B, Oellerich T, Ziegler N, Kannt A, Geisslinge… · 2026-09-30
open access unreviewed -
6
Oral Fungal Infection Impacts Epithelial Innate Immunity to Promote Local and Distal Squamous Cell Carcinoma Progression.
Li X, Singh AK, Song NY, Badger JH, Xavier das Neves R, Jiang C, Zhu F, Sun Z, Shi G, Willette-Brown J, Tross… · 2026-09-10
unreviewed -
7
UV irradiation drives lineage-specific MITF-mediated transcription of PD-L1 to confer immune tolerance to UV-mutated melanocytes.
Lo JA, Rachmin I, Flesher JL, Wu X, Kawakami A, Hejna M, Boozer JR, Nguyen N, King AD, Ji Y, Germana S, Kemen… · 2026-08-13
unreviewed -
8
WT1-Targeted Oral Bifidobacterium longum Vaccine Enhances Checkpoint Blockade Efficacy in Pancreatic Cancer.
Yamazaki T, Minami A, Hirota M, Hirano M, Sato R, Honma A, Ueki H, Shirakawa T. · 2026-07-07
open access unreviewed -
9
Integrated multi-omics decipher the complex nodule microbiota and distinct Frankiaceae symbiotic traits in wild actinorhizal plants.
Luo X, Lei Z, Fang D, Chen H, Qian L, Jin C, Wang X, Liu X, Liu H, Wang Y. · 2026-05-08
unreviewed -
10
Dynamic Switching of Apoptosis-Modulating Bim Heterodimers in Response to BH3 Mimetics in Xenograft Models of Hematologic Malignancies.
Govindharajulu JP, Fluss S, Hollingshead MG, Gillette W, Esposito D, Newton DL, Stockwin LH, Chen L, Jiwani S… · 2026-09-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.