unreviewed

dCMP deaminase

2 reactions · 2 pathways

Cofactors used

H2O

What it does, reaction by reaction

2 reactions

Deoxyribonucleotide Formation (Ribonucleotide Reductase pathway and thymidylate synthesis) Nucleotide Metabolism · Cytosol

step 5 Irreversible/directional

dCMP → dUMP

Converts dCMP into dUMP

› Notes

dCMP deaminase catalyzes dCMP + H2O → dUMP + NH3. The enzyme provides a second dUMP source and uses allosteric control to coordinate dCTP and dTTP pools; dCTP generally activates and dTTP inhibits the enzyme.

Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)

step 12 Irreversible/directional

dCMP → dUMP (alternative route)

Converts dCMP into dUMP

› Notes

dCMP deaminase catalyzes dCMP + H2O → dUMP + NH3. This allosterically regulated reaction provides another major dUMP source and contributes to balanced dCTP/dTTP pools.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Deoxyribonucleotide Formation (Ribonucleotide Reductase pathway and thymidylate synthesis)

Accelerated by

dCTP (allosteric activation)

Inhibited by

dTTP (allosteric inhibition)

Hormonal control

Cell-cycle-linked expression; no major direct endocrine allostery.

Recent literature

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