What it does, reaction by reaction
Pyrimidine Degradation Nucleotide Metabolism · Cytosol
Uridine → uracil
› Notes
Uridine phosphorylase catalyzes uridine + Pi ⇌ uracil + ribose 1-phosphate. Deoxyuridine can similarly be phosphorolyzed to uracil plus deoxyribose 1-phosphate.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Systematic metabolic engineering of <i>Escherichia coli</i> for high-level production of pseudouridine via pathway optimization and precursor enhancement.
Song J, Shen W, Xia Y, Zhou L, Zhou Y, Yang H, Chen X. · 2026-04-06
open access unreviewed -
2
Enhanced oral absorption and anti-colorectal cancer efficacy of trifluridine by interfering with both TPase and UPase.
Wan S, Fan X, Jin P, Wei M, Yang Q, Yu Y, Shao H, Widodo RT, Wu Y, Luo L. · 2026-07-08
unreviewed -
3
Comparative Analysis of LPS/IFN-γ and LPS/ATP-Induced Inflammatory Models in BV2 Microglia.
Zhang X, Lian Z, Lei S, Yi T, Zhao S, Liu M, Gui Y, Zhu C, Xie Q, Ma R. · 2026-08-07
unreviewed -
4
Pirinixic Acid Protects Against Hemorrhagic Shock by Regulating Neutrophil-Associated Key Genes.
Zhou X, Zou L, Deng H, Zhu Y, Zhang J, Li Q, Zhou S, Liu L, Wang L, Li T. · 2025-12-26
unreviewed -
5
Talarosterols A-C: Steroid-Xanthone Conjugates Featuring Octacyclic and Decacyclic Frameworks with Anti-Inflammatory Activity from Mangrove Endophytic Fungus <i>Talaromyces</i> sp.
Wang G, Mu R, Xue Z, Long Y, Chen Y, She Z. · 2026-07-09
unreviewed -
6
Integrative Single-Cell and Bulk Transcriptome Analysis Reveals Molecular Mechanisms, Prognostic Signatures, and Therapeutic Response in Glioma.
Xu X, Zhang C, Li Y, Miao C, Chen Z, Luo Q. · 2026-07-08
unreviewed -
7
Upregulation of macrophage UPP1 promotes lung adenocarcinoma metastasis through an mtROS-cGAS-NLRP3 inflammasome axis.
Feng M, Gao C, Yang Y, Li D, Zhou C, Chen L, Su Y, Cao Y, Li L, Gao Y. · 2026-07-06
unreviewed -
8
Centella Asiatica Alleviates Type 2 Diabetes-Related Hepatic Glycolipid Disorders via Regulating UPP1-Mediated Pyrimidine Metabolism.
Shen Y, Yao Y, Liu Z, Li Y, Cao S, Feng X. · 2026-06-27
unreviewed -
9
Metabolic Heterogeneity Across Heart Failure Subtypes Defined by Integrative Multi-Omics Analysis.
Xue Y, Liu L, Xu M, Jin L. · 2026-06-30
unreviewed -
10
MO-IPS suppresses acute myeloid leukemia through metabolic reprogramming and synergizes with anti-PD-1 immunotherapy.
Wang Y, Zhao W, Jin Y, Hu C, Fang X, Dong S, Zhang B. · 2026-06-17
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.