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MS
unreviewed

UDP-glucuronosyltransferase (UGT)

1 reactions · 1 pathways

Cofactors used

Clinical / pharmacological. Principal phase II route; UGT1A1 clears bilirubin and irinotecan metabolite SN-38

What it does, reaction by reaction

1 reactions

Phase II - Conjugation Xenobiotic & Drug Metabolism · Cytosol + ER

step 1 Irreversible/directional

Substrate + UDP-glucuronate -> glucuronide + UDP

Converts UDP-glucuronate into Glucuronide UDP

› Notes

Quantitatively the most important conjugation; the pathway that clears bilirubin (UGT1A1) and many drugs.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

Europe PMC · fetched just now · sorted by publication date

  1. 1
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    Rarely reported cases of hepatotoxicity associated with turmeric- and curcuminoid-containing dietary supplements: a comprehensive review by USP.

    Akhtar N, Barnes J, Gardiner P, Gurley BJ, Ko R, Koturbash I, Patel D, van Breemen RB, Roe AL. · 2026-06-27

    cited 1× open access unreviewed
  4. 4
    Metabolic engineering of <i>Saccharomyces cerevisiae</i> for co-production of ergothioneine, salidroside and gadusol.

    Zhang L, Xiao S, Wang D, Zhang P, Xu R, Hu L, Kang Z. · 2026-06-10

    open access unreviewed
  5. 5
  6. 6
    Functional characterization of four glycosyltransferases for biosynthesis of steroidal saponins in medicinal plant <i>Paris polyphylla</i>.

    Subthain H, Guo F, Zhang C, Fang P, Zhang L, Su Q, Tang D, Chi L, Liu C, Urlacher VB, Li J, Du L, Li S. · 2026-04-21

    open access unreviewed
  7. 7
    Efficient whole-cell biotransformation for gastrodin production via glycosyltransferase engineering and process optimization.

    Wang X, Zhang J, Li T, Wang F, Wang Z, Li X. · 2026-04-06

    open access unreviewed
  8. 8
    Functional identification of key enzymes in calycosin biosynthesis in <i>Astragalus membranaceus</i> and establishment of heterologous expression system.

    Cui MX, Hao Y, Li JN, Xu DD, Hao PX, Fu J, Lu Y, Li YT, Zhi LL, Zhang JZ, Lou HX, Cheng AX. · 2026-03-27

    open access unreviewed
  9. 9
    Advancing climate adaptation in saffron through CRISPR-based modulation of stress tolerance and photoperiodic flowering control.

    Ullah Q, Haider W, Zeshan M, Waqar M, Arshad MT, Parveen H, Mukhtar S, Zahir A, Zahir A. · 2026-02-10

    open access unreviewed
  10. 10

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.