UDP-glucuronosyltransferase (UGT)
Cofactors used
Clinical / pharmacological. Principal phase II route; UGT1A1 clears bilirubin and irinotecan metabolite SN-38
What it does, reaction by reaction
Phase II - Conjugation Xenobiotic & Drug Metabolism · Cytosol + ER
Substrate + UDP-glucuronate -> glucuronide + UDP
Converts UDP-glucuronate into Glucuronide UDP
› Notes
Quantitatively the most important conjugation; the pathway that clears bilirubin (UGT1A1) and many drugs.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Low-dose l-carnitine supplementation attenuates hepatic lipid accumulation in chow-fed mice: Insights from integrated multi-omics analysis.
Zhang Z, Ding B, Zhang L, Zhang L, Huang Y. · 2026-09-10
open access unreviewed -
2
Antiepileptic drug therapy in companion animals: New perspectives on clinical pathology monitoring.
Lotfalizadeh N, Nazifi S. · 2026-07-29
open access unreviewed -
3
Rarely reported cases of hepatotoxicity associated with turmeric- and curcuminoid-containing dietary supplements: a comprehensive review by USP.
Akhtar N, Barnes J, Gardiner P, Gurley BJ, Ko R, Koturbash I, Patel D, van Breemen RB, Roe AL. · 2026-06-27
cited 1× open access unreviewed -
4
Metabolic engineering of <i>Saccharomyces cerevisiae</i> for co-production of ergothioneine, salidroside and gadusol.
Zhang L, Xiao S, Wang D, Zhang P, Xu R, Hu L, Kang Z. · 2026-06-10
open access unreviewed -
5
The gut microbiome-bile acid-FXR interplay: a pivotal axis in metabolic and gastrointestinal diseases.
Shou J, Fu T. · 2026-05-01
cited 3× open access unreviewed -
6
Functional characterization of four glycosyltransferases for biosynthesis of steroidal saponins in medicinal plant <i>Paris polyphylla</i>.
Subthain H, Guo F, Zhang C, Fang P, Zhang L, Su Q, Tang D, Chi L, Liu C, Urlacher VB, Li J, Du L, Li S. · 2026-04-21
open access unreviewed -
7
Efficient whole-cell biotransformation for gastrodin production via glycosyltransferase engineering and process optimization.
Wang X, Zhang J, Li T, Wang F, Wang Z, Li X. · 2026-04-06
open access unreviewed -
8
Functional identification of key enzymes in calycosin biosynthesis in <i>Astragalus membranaceus</i> and establishment of heterologous expression system.
Cui MX, Hao Y, Li JN, Xu DD, Hao PX, Fu J, Lu Y, Li YT, Zhi LL, Zhang JZ, Lou HX, Cheng AX. · 2026-03-27
open access unreviewed -
9
Advancing climate adaptation in saffron through CRISPR-based modulation of stress tolerance and photoperiodic flowering control.
Ullah Q, Haider W, Zeshan M, Waqar M, Arshad MT, Parveen H, Mukhtar S, Zahir A, Zahir A. · 2026-02-10
open access unreviewed -
10
SGPP1 as a tumor suppressor in esophageal squamous cell carcinoma: Potential molecular mechanisms involving UGT1A9/UGT2B28 and clinical prognostic significance.
Su L, Hou L, Han X, Zhang G, Li J, Wang Y, Han Y, Xue X, Zhou H. · 2026-09-25
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.