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unreviewed

UDP-glucuronosyltransferase (UGT)

1 reactions · 1 pathways

Cofactors used

UDP-glucuronic acid

Clinical / pharmacological. Principal phase II route; UGT1A1 clears bilirubin and irinotecan metabolite SN-38

What it does, reaction by reaction

1 reactions

Phase II - Conjugation Xenobiotic & Drug Metabolism · Cytosol + ER

step 1 Irreversible/directional

Substrate + UDP-glucuronate -> glucuronide + UDP

Converts UDP-glucuronate into Glucuronide UDP

› Notes

Quantitatively the most important conjugation; the pathway that clears bilirubin (UGT1A1) and many drugs.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Metabolic engineering of <i>Saccharomyces cerevisiae</i> for co-production of ergothioneine, salidroside and gadusol.

    Zhang L, Xiao S, Wang D, Zhang P, Xu R, Hu L, Kang Z. · 2026-06-10

    open access unreviewed
  2. 2
    The gut microbiome-bile acid-FXR interplay: a pivotal axis in metabolic and gastrointestinal diseases.

    Shou J, Fu T. · 2026-05-01

    open access unreviewed
  3. 3
    Functional characterization of four glycosyltransferases for biosynthesis of steroidal saponins in medicinal plant <i>Paris polyphylla</i>.

    Subthain H, Guo F, Zhang C, Fang P, Zhang L, Su Q, Tang D, Chi L, Liu C, Urlacher VB, Li J, Du L, Li S. · 2026-04-21

    open access unreviewed
  4. 4
    Efficient whole-cell biotransformation for gastrodin production via glycosyltransferase engineering and process optimization.

    Wang X, Zhang J, Li T, Wang F, Wang Z, Li X. · 2026-04-06

    open access unreviewed
  5. 5
    Functional identification of key enzymes in calycosin biosynthesis in <i>Astragalus membranaceus</i> and establishment of heterologous expression system.

    Cui MX, Hao Y, Li JN, Xu DD, Hao PX, Fu J, Lu Y, Li YT, Zhi LL, Zhang JZ, Lou HX, Cheng AX. · 2026-03-27

    open access unreviewed
  6. 6
    Advancing climate adaptation in saffron through CRISPR-based modulation of stress tolerance and photoperiodic flowering control.

    Ullah Q, Haider W, Zeshan M, Waqar M, Arshad MT, Parveen H, Mukhtar S, Zahir A. · 2026-02-10

    open access unreviewed
  7. 7
    Testosterone and epitestosterone differentially regulate UDP-glucuronosyltransferases (UGT) activity.

    Xiao L, Qi J, Zhang Y, Li W, Zhu L, Liang S. · 2026-06-16

    unreviewed
  8. 8
    UDP-glycosyltransferases (UGTs) for the biocatalytic production of flavonoid di-glycosides.

    Li T, Nidetzky B. · 2026-06-01

    unreviewed
  9. 9
    Predicting intrinsic clearance using deep learning-based drug-metabolic enzyme interaction features on an IVIVE-harmonized endpoint dataset.

    Lee H, Kang H, Chae JW, Yun HY, Goo S, Namgoong H, Jung S. · 2026-05-20

    unreviewed
  10. 10
    Polyethylene glycol 400 improves the bioavailability and anti-inflammatory activity of quercetin by modulating metabolic enzymes and efflux transporters.

    Zhang M, Shang L, Zhao M, Zheng Y, Huang S, Wu W, Fang L, Zhang S, Zxxxhang M, Gao X. · 2026-08-13

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.