UDP-glucuronosyltransferase (UGT)
Cofactors used
Clinical / pharmacological. Principal phase II route; UGT1A1 clears bilirubin and irinotecan metabolite SN-38
What it does, reaction by reaction
Phase II - Conjugation Xenobiotic & Drug Metabolism · Cytosol + ER
Substrate + UDP-glucuronate -> glucuronide + UDP
Converts UDP-glucuronate into Glucuronide UDP
› Notes
Quantitatively the most important conjugation; the pathway that clears bilirubin (UGT1A1) and many drugs.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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