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unreviewed

UDP-glucose pyrophosphorylase

2 reactions · 2 pathways

Cofactors used

Mg2+ · Magnesium UTP PPi

What it does, reaction by reaction

2 reactions

Glycogenesis (Glycogen Synthesis) Carbohydrate Metabolism · Cytosol (glycogen particle)

step 3 Irreversible

Glucose-1-phosphate + UTP → UDP-glucose + PPi

Converts Glucose-1-phosphate UTP into UDP-glucose PPi

› Notes

UDP-glucose pyrophosphorylase requires UTP and Mg2+ to activate glucose as UDP-glucose. Subsequent hydrolysis of pyrophosphate by ubiquitous inorganic pyrophosphatase (PPi + H2O → 2 Pi) drives the overall activation forward; the activation sequence is effectively irreversible.

Uronic Acid Pathway Carbohydrate Metabolism · Cytosol

step 1 Irreversible/directional

Glucose-1-phosphate + UTP -> UDP-glucose + PPi

Converts Glucose-1-phosphate UTP into UDP-glucose PPi

› Notes

Shared entry with glycogenesis.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.

    Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01

    open access unreviewed
  2. 2
    Stepwise phage resistance and collateral phage susceptibility in <i>Klebsiella pneumoniae</i>.

    Yin X, Feng Y, Luo H, Fang Q, Yu J, McNally A, Zong Z. · 2026-05-29

    cited 1× open access unreviewed
  3. 3
    High-level biosynthesis of gastrodin in engineered Escherichia coli.

    Ge L, Jia R, Xu W, Xia Y, Pei J. · 2026-06-27

    unreviewed
  4. 4
    Fusion gene heterogeneity and kinase enrichment in high-grade serous carcinomas.

    Panagopoulos I, Stranger A, Sveen A, Jareid M, Kidd SG, Bischof K, Taskén K, Dørum A, Davidson B, Lothe RA, S… · 2026-06-25

    unreviewed
  5. 5
    Guanidinoacetic acid improves flesh quality associated with collagen synthesis and nucleotide metabolism in gibel carp CAS V (<i>Carassius gibelio</i>, CAS V).

    Wang Y, Zhang Y, Wu L, Li C, Chen Q, Han D, Liu H, Zhang Z, Xie S, Jin J. · 2026-04-03

    open access unreviewed
  6. 6
    Structure-coevolution dual-guided engineering of C-glycosyltransferase enables high-level biosynthesis of vitexin in <i>Yarrowia lipolytica</i>.

    Shi CQ, Chen YJ, Yang WL, Zheng S, Cai R, Hou J, Wang DQ, Sheng JZ. · 2026-03-09

    open access unreviewed
  7. 7
    Enzyme promiscuity-driven co-production of flavonoid 7-<i>O</i>-glycosides in engineered <i>Saccharomyces cerevisiae</i>.

    Tan X, Zuo S, Hu F, Xiao Z, Wang Y, Zhang S, Lu Q, Zhao Y, Chen J, Fan L, Liu J, Shan Y. · 2026-02-12

    cited 1× open access unreviewed
  8. 8
    <i>De novo</i> biosynthesis of eriocitrin in <i>Saccharomyces cerevisiae</i> through deep learning-guided enzyme screening and systematic metabolic engineering.

    Lu Q, Tan X, Zhang S, Wang Y, Zhao Y, Liu J, Hu F, Zuo S, Chen J, Fan L, Ding S, Xiao Z, Shan Y. · 2026-02-04

    cited 1× open access unreviewed
  9. 9
    Multi-Omics Analysis Reveals Impacts of SCARB1, TYR, and TYRP1 Knockouts on Pigmentation and Metabolic Pathways in Oujiang Color Common Carp.

    Kanika NH, Guo Z, Mandal RN, Hanif MS, Bao X, Chen X, Wang J, Wang C. · 2026-08-01

    unreviewed
  10. 10
    Genetic variants associated with reduced body size in indigenous chickens of Eritrea: A genome-wide association study.

    Habteslasie HA, Perini F, Ngeno K, Colombi D, Lasagna E, Dessie T, Kahi A. · 2026-07-27

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.