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unreviewed

UDP-glucose pyrophosphorylase

2 reactions · 2 pathways

Cofactors used

Mg2+ · Magnesium UTP PPi

What it does, reaction by reaction

2 reactions

Glycogenesis (Glycogen Synthesis) Carbohydrate Metabolism · Cytosol (glycogen particle)

step 3 Irreversible

Glucose-1-phosphate + UTP → UDP-glucose + PPi

Converts Glucose-1-phosphate UTP into UDP-glucose PPi

› Notes

UDP-glucose pyrophosphorylase requires UTP and Mg2+ to activate glucose as UDP-glucose. Subsequent hydrolysis of pyrophosphate by ubiquitous inorganic pyrophosphatase (PPi + H2O → 2 Pi) drives the overall activation forward; the activation sequence is effectively irreversible.

Uronic Acid Pathway Carbohydrate Metabolism · Cytosol

step 1 Irreversible/directional

Glucose-1-phosphate + UTP -> UDP-glucose + PPi

Converts Glucose-1-phosphate UTP into UDP-glucose PPi

› Notes

Shared entry with glycogenesis.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Identification of genetic determinants that promote biofilm growth under heterotrophic conditions in <i>Cupriavidus necator</i> using transposon enrichment.

    Weiler JR, Lapp CJ, Gescher J, Edel M. · 2026-09-01

    open access unreviewed
  2. 2
    A genome-wide CRISPR knockout screen identified host genes essential for Brucella invasion and intracellular survival.

    Wang X, Wu S, Ding Y, Ding J, Li P, Lian Z. · 2026-08-19

    open access unreviewed
  3. 3
    Multifaceted effects of <i>galU</i> deletion on phenotype and virulence of <i>Pseudomonas aeruginosa in vitro</i> and <i>in vivo</i>.

    Yu J, Wang J, Yang Y, Sun L, Hu X, Nie T, Yang X, Wang X, Li C, You X. · 2026-07-30

    cited 1× open access unreviewed
  4. 4
    Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.

    Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01

    open access unreviewed
  5. 5
    Stepwise phage resistance and collateral phage susceptibility in <i>Klebsiella pneumoniae</i>.

    Yin X, Feng Y, Luo H, Fang Q, Yu J, McNally A, Zong Z. · 2026-05-29

    cited 1× open access unreviewed
  6. 6
    Validation of next‑generation sequencing‑derived circulating mRNA variants as potential diagnostic tools in hepatocellular carcinoma and cholangiocarcinoma.

    Zezulinski D, Hoteit MA, Kaplan DE, Zhan T, Doria C, Block TM, Sayeed A. · 2026-09-18

    open access unreviewed
  7. 7
    Integrating genome-wide association study and transcriptomic profiling identifies candidate genes underlying soluble solids content in melon (<i>Cucumis melo</i> L.).

    Niu X, Li Q, Cao L, Liu Y, Qiang J, Lian Z, Xie Y, Meng Q, Yan W, Wang P, Li X, Mao W, Hou J, Li L, Yang L, F… · 2026-05-13

    open access unreviewed
  8. 8
    Crosstalk between alternative splicing and non-coding RNAs in hepatocellular carcinoma: from regulatory mechanism to therapeutic implications.

    Wang D, Zhong J, Liao Z. · 2026-08-07

    open access unreviewed
  9. 9
    Sevoflurane preconditioning attenuates myocardial cell damage caused by hypoxia and reoxygenation via regulating miR-92a-3p.

    Sun T, Bai Z, Zhang K, Li Y. · 2026-07-14

    unreviewed
  10. 10
    High-level biosynthesis of gastrodin in engineered Escherichia coli.

    Ge L, Jia R, Xu W, Xia Y, Pei J. · 2026-06-27

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.