Tyrosine hydroxylase (TH)
Cofactors used
Clinical / pharmacological. Rate-limiting for catecholamines; BH4-dependent
What it does, reaction by reaction
Catecholamine Synthesis Amino Acid & Nitrogen Metabolism · Cytosol + secretory vesicle
L-Tyrosine + O2 + BH4 -> L-DOPA + BH2 + H2O
Converts Tyrosine O2 BH4 into L-DOPA BH2 H2O
› Notes
Rate-limiting step of catecholamine synthesis; feedback-inhibited by the end-product catecholamines.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Advances in development of tuberculosis vaccines and preventive drug therapies: current pipeline, evidence, and access.
da Costa C, Marais BJ, Goletti D, Onyebujoh P, Chakaya J, Walzl G, Zumla A. · 2027-04-26
unreviewed -
2
Hypertensive disorders in pregnancies with early-onset fetal growth restriction: a retrospective cohort study.
Sabag DN, Fluss R, Yoeli-Ullman R, Tsur A. · 2026-07-26
unreviewed -
3
Trichodermin exhibits potent anti-glioblastoma activity by inducing cell cycle arrest and apoptosis, suppressing invasion, and enhancing temozolomide efficacy.
Tsai HP, Lee TH, Lin HL, Lin TW, Chang WH, Lin CJ. · 2026-07-20
unreviewed -
4
Planning and implementation of a community-wide tuberculosis screening intervention: a case study from Naujaat, Nunavut, Canada.
Xie XT, Batac ALR, Wills O, Kulleperuma K, Dhillon A, Palaniappan S, Agyemang EA. · 2026-07-14
unreviewed -
5
A qEEG-based prognostic model for cognitive impairment after ischemic stroke: Development and internal validation.
Nguyen VT, Quach THT, Do H, Duong KT, Bui KN, Ha H, Pham AG, Tran TC. · 2026-07-02
unreviewed -
6
Surveillance for <i>Coxiella burnetii</i> animal reservoirs in Hong Kong suggests low zoonotic risk of Q-fever from local animals including ruminants, companion animals and rodents.
Rizzo F, Nekouei O, Tam WYJ, Uea-Anuwong T, Magouras I, Bęczkowski P, Chan JCC, Wong SYH, Perroux TA, Flay KJ… · 2026-06-29
unreviewed -
7
Winter school and XVIII<sup>th</sup> symposium of the French Group of Bioelectrochemistry - Special issue editorial.
Lojou E, Barrière F. · 2026-07-07
unreviewed -
8
Thermal petiole wounding triggers trap closure in <i>Dionaea muscipula</i>.
Bergstrom N, Helfrich P. · 2026-07-09
unreviewed -
9
Well-being comparisons and mental health outcomes following loss: a two-wave longitudinal study.
Schlechter P, Hoppen TH, Bonanno GA, Morina N. · 2026-07-07
unreviewed -
10
Vitamin B6 produced by gut microbiome regulates host behavioral phenotypes through dopaminergic metabolism.
Kim D, Li M, Nguyen TH, Choi YJ, Jang S, Kim M, Kim YK, Shin MK, de Guzman ACV, Park S. · 2026-07-03
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.