rate-limiting unreviewed
Tyrosine hydroxylase (TH)
1 reactions · 1 pathways
Cofactors used
Clinical / pharmacological. Rate-limiting for catecholamines; BH4-dependent
What it does, reaction by reaction
1 reactions
Catecholamine Synthesis Amino Acid & Nitrogen Metabolism · Cytosol + secretory vesicle
step 1
Irreversible rate-limiting
L-Tyrosine + O2 + BH4 -> L-DOPA + BH2 + H2O
Converts Tyrosine O2 BH4 into L-DOPA BH2 H2O
› Notes
Rate-limiting step of catecholamine synthesis; feedback-inhibited by the end-product catecholamines.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
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