Tryptophan hydroxylase (TPH1/2)
Cofactors used
What it does, reaction by reaction
Serotonin & Melatonin Synthesis Amino Acid & Nitrogen Metabolism · Cytosol
L-Tryptophan + O2 + BH4 -> 5-hydroxytryptophan
Converts Tryptophan O2 BH4 into 5-Hydroxytryptophan
› Notes
Rate-limiting step.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Selective serotonin reuptake inhibitors and immune checkpoint blockade in solid tumors: A target trial emulation with pan-cancer transcriptomic analyses.
Chen PH, Dai MS, Huang MH, Chen HY, Kao LT, Hsieh TY, Jhou HJ, Lee CH. · 2026-09-29
open access unreviewed -
2
The Tryptophan-Kynurenine Pathway as a Key Mediator of the Gut-Brain Axis in Depression and Alzheimer's Disease.
Procopciuc LM, Hangan AC, Gog-Bogdan S, Lucaciu RL. · 2026-09-12
open access unreviewed -
3
Neonatal enteric infection disrupts the microbiota-gut-brain axis through pattern recognition receptors and altered neuroimmune signaling.
Park J, Orahood O, Banginwar M, Andrade A, Pore G, Sanchez K, Cremin M, Miller A, Reynoso-Garcia J, Lee S, Ju… · 2026-09-23
cited 2× open access unreviewed -
4
Brains, quacks, and boojums: a review of neurotransmitter and neuroendocrine bases of welfare and enrichment in poultry with an emphasis on the Pekin duck.
Schober JM, Bergman MM, Fraley GS. · 2026-09-02
open access unreviewed -
5
Tryptophan Metabolism in Digestive and Extra-Digestive Diseases: Mechanisms, Clinical Implications, and Therapeutic Perspectives.
Tohumcu E, Puca FS, Tunali V, Cerrito L, Pallozzi M, Stella L, Maestri M, Murace CA, Porcari S, Varca S, Seve… · 2026-09-01
open access unreviewed -
6
Compensatory pathways in tryptophan metabolism and immune regulation following IDO inhibition.
Gontijo I, Camurça M, Kfoury JR. · 2026-09-12
open access unreviewed -
7
Metabolic shifts driven by host-microbial interactions.
Nair T, Stuhr NL, Weathers BA, Curran SP. · 2026-09-01
unreviewed -
8
From depression to bone health: examining the skeletal effects of classical and rapid-acting antidepressants.
Louka P, Pitsillides AA, Koumas M, Papacharalambous C, Sophocleous A, Zanos P. · 2026-09-01
open access unreviewed -
9
Neuromodulation techniques targeting neurotransmitter dysfunction: Innovation in treatments for Alzheimer's disease.
Jin S, Guo B, Hao W, Su X, Zhang T, Liu C. · 2025-10-30
open access unreviewed -
10
A Functional SNP in the Promoter Region of Ovine IDO2 Associated With Melatonin Levels via Affecting Transcription Activity by CLOCK.
Jiang X, Chi S, Wang X, Chen M, Tie Z, Yang H, Wang C, Liu G. · 2026-08-01
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.