What it does, reaction by reaction
Pyrimidine Degradation Nucleotide Metabolism · Cytosol
Thymidine → thymine
Converts Thymidine into Thymine
› Notes
Thymidine phosphorylase catalyzes thymidine + Pi ⇌ thymine + 2-deoxyribose 1-phosphate. The reaction also participates in thymidine salvage, depending on metabolite concentrations.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
HSV-1 metabolic hijacking: Mechanisms to precision therapeutics.
Kuang S, Zhang J, Chen J, He Z, Yang J, Li S, Ding J, Ma Z, Zhang B. · 2026-08-11
open access unreviewed -
2
Exploring the gut microbiome and metabolomic interactions of antimetabolite drugs to optimize therapy.
Chen J, Wang Y, Xu L, Li X, Zhao L. · 2026-02-27
cited 1× open access unreviewed -
3
Microbes and medicines: interrelationships between pharmaceuticals and the gut microbiome.
Al-Btoosh S, Donnelly RF, Kelly SA. · 2025-12-23
cited 12× open access unreviewed -
4
Triazole-Linked Pyrimidine Nucleoside Dimers: Design, Synthesis, and Applications in Medicinal and Nucleic Acid Chemistry. Part IV.
Baraniak D, Wawrzyniak D, Baranowski D. · 2026-10-01
open access unreviewed -
5
Citrullination-associated transcriptional states identify a non-canonical invasive program in malignant epithelial cells and correlate with SPP1-CD44 immune microenvironment niches in thyroid cancer.
Tian Z, Zhu P, Zhao X, Yang F. · 2026-08-05
open access unreviewed -
6
Histogenetic Classification Predicts Outcomes in 130 Adults With Chronic Intestinal Pseudo-Obstruction.
Ta MC, Cazals-Hatem D, Billiauws L, Amiot A, Bellaiche M, Berrebi D, Coffin B, Corcos O, Ecochard-Dugelay E, … · 2026-03-02
cited 2× open access unreviewed -
7
Conformation- and Compound-Dependence of Ribose/2'-Deoxyribose Retention Patterns in Pyrimidine-Nucleoside Phosphorylase from <i>Bacillus subtilis</i>: A Four-Structure Molecular Dynamics Study.
Hatano A, Takeshima K. · 2026-09-12
open access unreviewed -
8
Prenatal and Postnatal Identification of Phelan-McDermid Syndrome in a Tertiary Referral Center: A 15-Case Series and Literature Review.
Xue H, Dai Y, Ye X, Zhang L, Guo Q, Lin N, Huang H, Xu L. · 2026-09-14
open access unreviewed -
9
Antioxidants in Oxidative Stress and Obesity-Associated Diseases: Molecular Mechanisms and Potential Health Implications.
Tan BL. · 2026-09-11
open access unreviewed -
10
Ribonucleotides Amplify Mitochondrial DNA-Driven cGAS-STING Activation via FdUMP-ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy.
Wang C, Zhao C, Yao Y, Zou Z, Shi A, Feng Z, Yang M, Yu Y, Liu Y, Rui X, Wu J. · 2026-09-21
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.