What it does, reaction by reaction
Pyrimidine Degradation Nucleotide Metabolism · Cytosol
Thymidine → thymine
Converts Thymidine into Thymine
› Notes
Thymidine phosphorylase catalyzes thymidine + Pi ⇌ thymine + 2-deoxyribose 1-phosphate. The reaction also participates in thymidine salvage, depending on metabolite concentrations.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Exploring the gut microbiome and metabolomic interactions of antimetabolite drugs to optimize therapy.
Chen J, Wang Y, Xu L, Li X, Zhao L. · 2026-02-27
open access unreviewed -
2
Microbes and medicines: interrelationships between pharmaceuticals and the gut microbiome.
Al-Btoosh S, Donnelly RF, Kelly SA. · 2025-12-23
cited 5× open access unreviewed -
3
Enhanced oral absorption and anti-colorectal cancer efficacy of trifluridine by interfering with both TPase and UPase.
Wan S, Fan X, Jin P, Wei M, Yang Q, Yu Y, Shao H, Widodo RT, Wu Y, Luo L. · 2026-07-08
unreviewed -
4
Identification and validation of key genes as diagnostic biomarkers for epilepsy using bioinformatics and machine learning.
Wu L, Huang Y, Yang H, Zhang C, Feng D, Zhou G. · 2026-02-24
unreviewed -
5
Multiplexed quantitative proteomics in small-cell lung cancer: stage-linked DLL3 distribution and an independent prognostic signal of thymidine phosphorylase.
Kim TE, Hong SH, An HJ, Lim JU, Park CK, Yoon HK, Sa YJ, Kim HR, Kim TJ. · 2026-06-26
unreviewed -
6
2-deoxy-d-ribose: A multifaceted player at the crossroads of cancer metabolism.
Kersten MC, Witt M, Stiewe T, Gremke N, Taudte RV. · 2026-07-27
unreviewed -
7
Plasma Exosomes Associated with Growth Divergence in High-Density Cultured Grass Carp (<i>Ctenopharyngodon idella</i>): miRNA-Protein Profiling Reveals Cross-Tissue Communication Networks.
Zhu T, Zheng Z, Chen H, Yu Y, Guo H, Liu B, Zhu K, Zhang N, Xian L, Zheng S, Liu Y, Chen S, Zhang D. · 2026-07-06
unreviewed -
8
Integrative analysis prioritizes proteins associated with renal cell carcinoma and its risk factors.
Sajal IH, Song AJ, Brown KM, Machiela MJ, Kraft P, Chanock S, Purdue MP, Dutta D. · 2026-07-13
unreviewed -
9
2'-Deoxyuridine-promoted infection in <i>Pyricularia oryzae</i> is counteracted by bacterial thymidine phosphorylase.
Hu H, Maeshima H, Tsukahara R, Ashida A, Kano K, Mishiro-Sato E, Chiba S, Takemoto D, Sato I. · 2026-07-13
unreviewed -
10
Interaction of G2019S LRRK2 and metabolic syndrome in a two-hit mouse model of Parkinson's disease: LRRK2-driven systemic depletion of pyrimidine nucleosides.
Ma Y, Erb ML, Sipple KA, Offerman AV, Niu J, Madaj ZB, Fu Z, Lau KH, Moore DJ. · 2026-07-08
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.