Acyl-CoA dehydrogenase (VLCAD/LCAD/MCAD/SCAD)
Cofactors used
Clinical / pharmacological. MCAD deficiency: hypoketotic hypoglycaemia, dicarboxylic aciduria, SIDS-like presentation
What it does, reaction by reaction
Beta-Oxidation of Fatty Acids Lipid Metabolism · Mitochondrial matrix (peroxisome for VLCFA)
Fatty acyl-CoA + FAD → trans-Δ2-enoyl-CoA + FADH2
Converts Fatty acyl-CoA FAD into trans-Delta-2-Enoyl-CoA FADH2
› Notes
An acyl-CoA dehydrogenase catalyzes the first recurring oxidation. Very-long-, long-, medium-, or short-chain acyl-CoA dehydrogenase is selected by chain length; electrons pass from FADH2 through electron-transfer flavoprotein (ETF) and ETF:ubiquinone oxidoreductase to the ubiquinone pool. This is not directly ATP-producing but yields respiratory-chain reducing equivalents.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Beta-Oxidation of Fatty Acids
Listed there as: Acyl-CoA dehydrogenases (including MCAD)
ADP demand, NAD+/FAD regeneration, substrate supply
High NADH/NAD+ ratio; respiratory-chain impairment
Fasting hormones increase fatty-acid delivery; transcriptional control is mediated partly by PPARα in liver
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Integrated transcriptome and metabolome reveal <i>Mycoplasma hyopneumoniae</i> -induced lipid accumulation, inflammation, oxidative stress, and energy imbalance in the liver of pigs.
Xue X, Bu Y, Yu C, Li J, Yang J, Gao M, Wang P, Gan Y, Zhang W, Fan S, Zhou R, Yin Z, Zheng X. · 2026-06-03
cited 1× open access unreviewed -
2
Hypophosphatasia: Results of a Country-Wide Selective Screening Program Using NGS Technology as a First-Tier Test.
Pushkov AA, Zhanin IS, Chudakova DA, Rusakova AA, Demianov DS, Pakhomov AV, Koroleva VB, Koshevaya YS, Burlac… · 2026-08-04
open access unreviewed -
3
GIPC1 governed ferroptosis by regulating DECR1-modulating lipid homeostasis during dilated cardiomyopathy (DCM).
Tang N, Mu R, Wang H, Wu J, Zhang J, Huang D, Han Y, Li W, Chen Y, Li X, Sun Y, Zhang Z, Zuo J, Hu Y, Yin Y, … · 2026-03-05
cited 2× open access unreviewed -
4
Placental lipid handling, growth and inflammatory pathways are modified by a maternal Mediterranean diet.
Lopez-Tello J, Youssef L, Bermejo-Poza R, Cabezas A, De la Fuente J, Crovetto F, Gratacos E, Crispi F, Sferru… · 2026-07-28
open access unreviewed -
5
CPT2 as a Convergent Node Linking Age-Associated Neuronal H3K27me3 Remodeling to Nicotinamide Mononucleotide (NMN)-Induced Expression Rescue in Metabolic Tissues.
Cheung N. · 2026-07-18
cited 1× open access unreviewed -
6
ER stress-mediated impairment of hepatic lipid export is associated with steatosis in AKI-induced remote liver injury.
Li M, Ni R, Williams K, Melaika M, Sun LE, Fu L, Subramanian V, Dhanireddy K, Liu R. · 2026-06-29
open access unreviewed -
7
Lipid Metabolic Reprogramming and Epigenetic Co-Dysregulation Across the Central Chondrosarcoma Grade Spectrum: A Multi-Cohort RNA-seq Study
Ayhan B, Dönmez N, Ayhan Z. · 2026-06-01
open access unreviewed -
8
Analysis of differentially expressed genes related to acute lung injury and their role in metabolic pathways: An integrative study using GEO data.
Yang Y. · 2026-05-01
open access unreviewed -
9
Natural Plant-Derived Compounds Targeting Oxidative Stress and Inflammation in NAFLD-Mechanisms and Repositioning Potential.
Theodorou RE, Vrettos N, Theodosis-Nobelos P. · 2026-04-29
cited 1× open access unreviewed -
10
Integrated Analysis of Transcriptome and Metabolome Reveals Molecular Responses to Ammonia Stress in the Gills of <i>Litopenaeus vannamei</i> Under Low-Salinity Conditions.
Zhao Y, Ding Y, Zhou F, Hu X, Yang Q, Cao Y. · 2026-04-13
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.