What it does, reaction by reaction
Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol
Palmitoyl-ACP + H2O → palmitate + ACP
Converts Palmitoyl-ACP H2O into Palmitate ACP (acyl carrier protein)
› Notes
The thioesterase (TE) domain of FAS hydrolyzes palmitoyl-ACP, terminating synthesis predominantly at C16. This is effectively irreversible by hydrolysis, but ACC—not thioesterase—is the pathway’s principal rate-limiting step.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
3D-printed niche-matched GelMA-dECM bioinks rewire lipid metabolic reprogramming and chemosensitization in pancreatic ductal adenocarcinoma.
Zhu B, Yang T, Chang M, Li Y, Wu D, Yan J, Guo Q, Wan J, Guo Y, Lu Y. · 2026-08-20
unreviewed -
2
VCP at the crossroads of UPS and autophagy in cancer.
Hitchman CJ, Phillips JI, Park HW, Lu H. · 2026-05-28
open access unreviewed -
3
Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.
Xiao W, Tan D, Zeng W, Nie X, Wang M. · 2026-01-28
open access unreviewed -
4
Pharmacological inhibition of CLPP stabilizes LETMD1 to boost thermogenesis and alleviate obesity.
Yuan H, Deng Y, Wang J, Luan B, Zhang ZN. · 2026-09-30
open access unreviewed -
5
Low-dose l-carnitine supplementation attenuates hepatic lipid accumulation in chow-fed mice: Insights from integrated multi-omics analysis.
Zhang Z, Ding B, Zhang L, Zhang L, Huang Y. · 2026-09-10
open access unreviewed -
6
From candidate genes to whole-genome approaches: current insights into the genetic architecture of ovine milk production and quality traits.
Mastrangelo S, Benanti A, Tumino S, Criscione A, Cesarani A. · 2026-09-15
open access unreviewed -
7
Effects of <i>Lactobacillus acidophilus</i> on hepatic and microbial dysregulation in MASLD and diabetes.
Park HJ, Park IG, Park JH, Park HJ, Jung JJ, Han SH, Suk KT. · 2026-09-19
open access unreviewed -
8
Hepatocyte SLC31A1-dependent copper accumulation contributes to hepatic glucose and lipid metabolic disturbances through AMPKα1 inactivation.
Cheng YQ, Wei M, Yang L, Zhuang YY, Lu QB. · 2026-09-11
open access unreviewed -
9
Distinct functional roles of <i>Lactobacillus</i> strains in modulating lipid metabolism, adipose accumulation, inflammatory responses, and carcass characteristics in heavy finishing pigs.
Wan B, Zeng Q, He L, Qin X, Tan M, Yan E, Liao J, Li Z, Zhang X, Yin J. · 2026-07-31
open access unreviewed -
10
Epigallocatechin gallate (EGCG) inhibits African swine fever virus replication by targeting key viral proteins and regulating host lipid metabolism.
He X, Li H, Yang R, Li P, Wang G, Cao H, Sun Y, Zhang M, Li Y, Shi K, Jongkaewwattana A, Ruan S, Li W. · 2026-09-18
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.