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unreviewed

Serotonin N-acetyltransferase (AANAT) + ASMT/HIOMT

1 reactions · 1 pathways

Cofactors used

Acetyl-CoA SAM

Clinical / pharmacological. Slow acetylators: isoniazid neuropathy, hydralazine/procainamide lupus

What it does, reaction by reaction

1 reactions

Serotonin & Melatonin Synthesis Amino Acid & Nitrogen Metabolism · Cytosol

step 3 Irreversible/directional

Serotonin + acetyl-CoA -> N-acetylserotonin; then + SAM -> melatonin

Converts Serotonin Acetyl-CoA into N-Acetylserotonin Then S-adenosylmethionine (SAM)

› Notes

Pineal, night-time. AANAT is the rate-controlling, light-suppressed step.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Tryptophan Metabolism in Digestive and Extra-Digestive Diseases: Mechanisms, Clinical Implications, and Therapeutic Perspectives.

    Tohumcu E, Puca FS, Tunali V, Cerrito L, Pallozzi M, Stella L, Maestri M, Murace CA, Porcari S, Varca S, Seve… · 2026-09-01

    open access unreviewed
  2. 2
    Miscompartmentalization of microbiota-derived TMAO is a reversible driver in autism spectrum disorder.

    Launay JM, Vodovar N. · 2026-08-24

    open access unreviewed
  3. 3
    The Circadian-Melatonin Axis in Bone Remodeling: Receptor-Dependent Signaling, Receptor-Independent Actions, and Translational Constraints.

    Lin CC, Hou YC, Hsiao PJ, Lu KC. · 2026-08-25

    open access unreviewed
  4. 4
    Expression of Rate-Limiting Enzymes of Melatonin Synthesis in Several Extrapineal Organs During Pregnancy in Ewes.

    Xu Y, Hou H, Yang Y, Gao D, Zhang L, Yang L. · 2026-07-17

    open access unreviewed
  5. 5
    Hierarchical Disruption of the Tryptophan-Melatonin Axis Contributes to Glioma Progression Through AKT/ERK/STAT3 Signalling.

    Tan B, Yao S, He S, Chen T, Chen H, Yang W, Tang X, Xu T, Zhang J, Yin X, Chen Y, Song P. · 2026-06-01

    cited 1× open access unreviewed
  6. 6
    Molecular Evidence for the Parallel Evolution of Anosmia in Multiple Odontoceti (Toothed Whales) Clades.

    Springer MS, McGowen MR, Gatesy J. · 2026-05-31

    open access unreviewed
  7. 7
    Tryptophan metabolism in glaucomatous optic neuropathy: from metabolic dysregulation to therapeutic opportunities.

    Wang N, Yan T, Sun H, Guo W. · 2026-04-22

    open access unreviewed
  8. 8
    Synaptic Plasticity Fragility Underlies a Microglial Pruning Continuum in Major Depressive Disorder and Amyotrophic Lateral Sclerosis.

    Cheung N. · 2026-04-17

    cited 2× open access unreviewed
  9. 9
    Optimizing Brain Biology Through Near-Infrared-Induced Mitochondrial Melatonin Synthesis: A Hypothesis Paper.

    Mercola J. · 2026-03-16

    open access unreviewed
  10. 10
    Melatonin ameliorates autistic-like behaviors by restoring gut microbiota-derived tryptophan metabolites.

    Shen J, Gao J, Gao L, Yan D, Wang Y, Meng J, Li H, Chen D, Wu J. · 2026-03-05

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.