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unreviewed

Serotonin N-acetyltransferase (AANAT) + ASMT/HIOMT

1 reactions · 1 pathways

Cofactors used

Acetyl-CoA SAM

Clinical / pharmacological. Slow acetylators: isoniazid neuropathy, hydralazine/procainamide lupus

What it does, reaction by reaction

1 reactions

Serotonin & Melatonin Synthesis Amino Acid & Nitrogen Metabolism · Cytosol

step 3 Irreversible/directional

Serotonin + acetyl-CoA -> N-acetylserotonin; then + SAM -> melatonin

Converts Serotonin Acetyl-CoA into N-Acetylserotonin Then S-adenosylmethionine (SAM)

› Notes

Pineal, night-time. AANAT is the rate-controlling, light-suppressed step.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Hierarchical Disruption of the Tryptophan-Melatonin Axis Contributes to Glioma Progression Through AKT/ERK/STAT3 Signalling.

    Tan B, Yao S, He S, Chen T, Chen H, Yang W, Tang X, Xu T, Zhang J, Yin X, Chen Y, Song P. · 2026-06-01

    open access unreviewed
  2. 2
    Molecular Evidence for the Parallel Evolution of Anosmia in Multiple Odontoceti (Toothed Whales) Clades

    Springer M, McGowen M, Gatesy J. · 2026-05-31

    open access unreviewed
  3. 3
    Tryptophan metabolism in glaucomatous optic neuropathy: from metabolic dysregulation to therapeutic opportunities.

    Wang N, Yan T, Sun H, Guo W. · 2026-04-22

    open access unreviewed
  4. 4
    Synaptic Plasticity Fragility Underlies a Microglial Pruning Continuum in Major Depressive Disorder and Amyotrophic Lateral Sclerosis.

    Cheung N. · 2026-04-17

    open access unreviewed
  5. 5
    Optimizing Brain Biology Through Near-Infrared-Induced Mitochondrial Melatonin Synthesis: A Hypothesis Paper.

    Mercola J. · 2026-03-16

    open access unreviewed
  6. 6
    Melatonin ameliorates autistic-like behaviors by restoring gut microbiota-derived tryptophan metabolites.

    Shen J, Gao J, Gao L, Yan D, Wang Y, Meng J, Li H, Chen D, Wu J. · 2026-03-05

    open access unreviewed
  7. 7
    Physiological relevance of autocrine melatonin signaling in pineal and extrapineal sites: a systematic review.

    Ndinganire G, Ntamukunzi G, Alagbonsi AI. · 2026-01-19

    cited 2× open access unreviewed
  8. 8
    Melatonin Biosynthesis, Receptors, and the Microbiota-Tryptophan-Melatonin Axis: A Shared Dysbiosis Signature Across Cardiac Arrhythmias, Epilepsy, Malignant Proliferation, and Cognitive Trajectories.

    Tavartkiladze A, Reiter RJ, Lou R, Kasradze D, Okrostsvaridze N, Revazishvili P, Maisuradze M, Dundua G, Andr… · 2026-01-29

    open access unreviewed
  9. 9
    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications.

    Gonciarz M, Wiatrak B, Lombard I, Konecki Ł, Sarbinowska J. · 2026-01-01

    cited 2× open access unreviewed
  10. 10
    Melatonin promotes cytotoxicity while reducing cell motility and antioxidant defenses in ovarian cancer cell lines.

    Silveira HS, Cesário RC, Simão VA, Guimarães F, Seiva FRF, Zuccari DAPC, Fernandes GSA, de Souza MC, Reiter R… · 2025-10-28

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.