What it does, reaction by reaction
Methionine Cycle / Transmethylation (SAM Cycle, homocysteine) Amino Acid & Nitrogen Metabolism · Cytosol
SAM + methyl acceptor → S-adenosylhomocysteine (SAH) + methylated acceptor
Converts S-adenosylmethionine (SAM) into S-adenosylhomocysteine (SAH)
› Notes
A large family of SAM-dependent methyltransferases transfers the activated methyl group to substrates such as DNA, RNA, norepinephrine, phosphatidylethanolamine, guanidinoacetate, and catechols. No additional ATP is used in the transfer, but SAM cleavage makes methyl transfer strongly favorable; this is the defining transmethylation step.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
A Wagner-Meerwein-Like Rearrangement Generates a Vinyl Group in the Biosynthesis of the Polychlorinated Lipopeptides Fischerazoles.
Figueiredo SAC, Abt K, Viehrig K, Jervis PJ, Martins TP, Lacomba I, Li C, Castagnolo D, Leão PN. · 2026-07-07
unreviewed -
2
SAM-dependent methyltransferases: from chemoenzymatic natural product synthesis to industrial application.
Böhmer LM, Chapple BP, Amariei DA, Hayes MA, Pietruszka J. · 2026-07-01
unreviewed -
3
Impact of mitochondrial reductive stress due to respiratory chain limitation on cancer via posttranslational modifications.
Chinopoulos C. · 2026-05-16
open access unreviewed -
4
The Interplay of Splicing and Metabolism in Cancer.
Voss DM, Cui Y, Klein PS. · 2026-06-20
cited 1× open access unreviewed -
5
Structural dynamics of the π-stacking network governing cofactor-substrate cooperativity of SbSOMT methyltransferase.
Pow KC, Zhang N, Yan M, Wang X, Lui ACW, Lo C, Hao Q. · 2026-06-08
unreviewed -
6
Molecular insights into juvenile hormone maturation by juvenile hormone acid methyltransferase.
Picard MÈ, Cusson M, Shi R. · 2026-04-17
open access unreviewed -
7
One-carbon metabolism and cardiovascular disease: Molecular mechanisms, genetic influences, and epigenetic regulation.
Al Qassab M, Bou Ghanem A, Hussayni Y, Kadbey R, Ratel Y, Yehya S, Zahr M, Ghadieh HE, Abi Khattar Z, Azar S,… · 2026-03-17
open access unreviewed -
8
The complex link of the folate-homocysteine axis to myocardial hypertrophy and heart failure: from mechanistic exploration to clinical vision.
Wang Y, LaBapuchi, Liu M, Chen L. · 2025-09-19
cited 1× open access unreviewed -
9
Sulfur-Containing Amino Acids: The Conversion Process from Product to Substrate.
Zheng P, Jin Y, Wei C, Xia C. · 2026-05-26
open access unreviewed -
10
Inhibition of human histone lysine methyltransferases by a redox-labile S-adenosyl-L-homocysteine analog.
Voukia F, Moesgaard L, Kongsted J, Mecinović J. · 2026-05-13
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.