What it does, reaction by reaction
Methionine Cycle / Transmethylation (SAM Cycle, homocysteine) Amino Acid & Nitrogen Metabolism · Cytosol
SAM + methyl acceptor → S-adenosylhomocysteine (SAH) + methylated acceptor
Converts S-adenosylmethionine (SAM) into S-adenosylhomocysteine (SAH)
› Notes
A large family of SAM-dependent methyltransferases transfers the activated methyl group to substrates such as DNA, RNA, norepinephrine, phosphatidylethanolamine, guanidinoacetate, and catechols. No additional ATP is used in the transfer, but SAM cleavage makes methyl transfer strongly favorable; this is the defining transmethylation step.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Nutrigenomic regulation of one-carbon metabolism and the circadian clock in health and disease.
Fustin JM. · 2026-10-01
open access unreviewed -
2
Discovery and Biosynthetic Characterization of Darumycins Expand the Chemical Space of Sesterterpene Antibiotics.
Bratiichuk D, Kolling D, Redzic I, Stierhof M, Fries F, Zapp J, Müller R, Myronovskyi M, Koehnke J, Luzhetsky… · 2026-08-19
open access unreviewed -
3
S-Adenosylmethionine-Dependent Methylation, Protein Arginine Methyltransferases and Cardiovascular Diseases.
Yan Z, Zhao W, Zhao N, Li J. · 2026-09-19
open access unreviewed -
4
Rv3787c Influences Growth Dynamics of <i>Mycobacterium tuberculosis</i>.
Bigi MM, Rocha RV, García EA, Blanco FC, Bigi F. · 2026-09-20
open access unreviewed -
5
Tied to Work: Topologically Knotted SPOUT Methyltransferases and UCH Deubiquitinases in Cellular Biochemistry.
Hsu SD. · 2026-09-01
unreviewed - 6
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7
Molecular basis of tRNA substrate recognition and modification by the atypical SPOUT methyltransferase Trm10.
Nandi S, Strassler SE, Dey D, Whitney CB, Roumaya OB, Krishnamohan A, Harris GM, Comstock LR, Jackman JE, Con… · 2026-09-01
open access unreviewed -
8
Adenosine 5'-Carboxamide-Based Inhibitors of METTL1.
Bobileva O, Nai F, Niedrite S, Mayordomo Soler L, Leite I, Caflisch A. · 2026-08-10
open access unreviewed -
9
Sustainable Biocatalytic Cascades: A Versatile Tool in the Synthesis of Natural Products With Therapeutic Potential.
Yadav RN, Dey S, Pandey SK, Barman A, Hossain MF, Schmidt LC, Singh V. · 2026-09-01
unreviewed -
10
Uncovering the genetic basis of fruit volatiles in <i>Fragaria vesca</i> through GWAS reveals FvJMT2 as a methyl benzoate biosynthesis gene with bioactivity against <i>Drosophila suzukii</i>.
Jiménez-Muñoz R, Urrutia M, Meco V, Rambla JL, Toivainen T, Pérez-Hedo M, Sánchez-Sevilla JF, Urbaneja A, Sal… · 2026-04-16
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.