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unreviewed

SAICAR synthetase

1 reactions · 1 pathways

Cofactors used

ATP Pi

What it does, reaction by reaction

1 reactions

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol

step 8 Irreversible/directional

CAIR → succinylaminoimidazolecarboxamide ribonucleotide (SAICAR)

Converts Carboxyaminoimidazole ribonucleotide (CAIR) into SAICAR

› Notes

SAICAR synthetase catalyzes CAIR + aspartate + ATP → SAICAR + ADP + Pi. Aspartate donates N1 of the purine ring, while its carbon skeleton is later released as fumarate.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Integrating bulk and single-cell transcriptomic data to construct a risk model for histidine metabolism-related epithelial cell features in lung adenocarcinoma, predicting prognosis and immune landscape.

    Mao C, Zhou L. · 2026-04-28

    open access unreviewed
  2. 2
    Guanidinoacetic acid improves flesh quality associated with collagen synthesis and nucleotide metabolism in gibel carp CAS V (<i>Carassius gibelio</i>, CAS V).

    Wang Y, Zhang Y, Wu L, Li C, Chen Q, Han D, Liu H, Zhang Z, Xie S, Jin J. · 2026-04-03

    open access unreviewed
  3. 3
    Compound Heterozygous Variants in the PAICS Gene Integrate the Previously Described Divergent Phenotypes.

    Monti L, Isidori F, Capriotti E, Minicucci A, Michelangelo B, Di Mitri M, Scarano E, Lima M, Pippucci T, Seve… · 2026-08-08

    unreviewed
  4. 4
    N6-methyladenosine-mediated upregulation of PAICS promotes lung-adenocarcinoma metastasis via the integrin-FAK signaling.

    Zhang M, Zhu J, Zhang H, Zhang J, Zhao J, Chen Q, Zeng Y, Li J, Huang JA, Liu Z. · 2026-07-23

    unreviewed
  5. 5
    Alphavirus nsP3 as a multifunctional orchestrator of virus-host interplay.

    Pimenta-Pereira AA, Lubinski B, Campos RK. · 2026-06-15

    unreviewed
  6. 6
    Gene Expression and Structural Differences Underpinning Black and White Colouration in Spiders.

    Salgado-Roa FC, Stuart-Fox D, Ospina-Rozo L, Medina I. · 2026-06-01

    open access unreviewed
  7. 7
    Integrated Single-Cell Virtual Knockout and Machine Learning Analyses Reveal a Protective Role of CKAP2 in Gastric Cancer.

    Yang J, Qiu Z, Song W, Liu X, Ouyang T, Shu J, Wang J, Yang Y. · 2026-06-01

    open access unreviewed
  8. 8
    Host metabolic responses to SARS-CoV-2 and influenza viruses: parallels and contrasts.

    Terra C, Terrier O, Le Gouellec A. · 2026-06-02

    open access unreviewed
  9. 9
    A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity.

    Jaiswal AK, Scherer GM, Thaxton ML, Sorrentino JP, Yuen C, Mehta MM, Sharma G, Lin TL, Tran TM, Cohen A, Ritt… · 2025-11-27

    cited 4× open access unreviewed
  10. 10
    Gene Flow Complicates Phylogenetic Inference in an Archipelago Radiation.

    Gyllenhaal EF, Klicka LB, DeCicco LH, Weeks BC, Moyle RG, Andersen MJ. · 2026-06-01

    cited 2× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.