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unreviewed

S-adenosylhomocysteine hydrolase (AHCY)

1 reactions · 1 pathways

Cofactors used

H2O

What it does, reaction by reaction

1 reactions

Methionine Cycle / Transmethylation (SAM Cycle, homocysteine) Amino Acid & Nitrogen Metabolism · Cytosol

step 3 Reversible

SAH + H₂O ⇌ homocysteine + adenosine

Converts S-adenosylhomocysteine H2O into Homocysteine Adenosine

› Notes

S-adenosylhomocysteine hydrolase (AHCY) catalyzes a reversible reaction whose in vivo direction is driven toward hydrolysis by rapid removal of homocysteine and adenosine. SAH is a potent competitive inhibitor of many methyltransferases, so its clearance is necessary to preserve methylation potential.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Nutrigenomic Regulation of One-Carbon Metabolism and the Circadian Clock in Health and Disease.

    Fustin JM. · 2026-07-01

    unreviewed
  2. 2
    Asarinin attenuates ferroptosis resistance by inhibiting the activity of S-adenosyl homocysteine hydrolase in lung cancer.

    Li Z, Wang Y, Huang Z, Wang Z, Guo Z, Xu E, Zheng Y. · 2026-05-13

    unreviewed
  3. 3
    The GNMT N-terminus Couples Folate Feedback to Methyl-donor Homeostasis

    · 2026-05-29

    open access unreviewed
  4. 4
    Moderate Methionine Reduction Alleviates Lipopolysaccharide-Induced Stress in Broiler Chickens by Enhancing Antioxidant Pathways.

    Niu J, Dong Y, Du M, Zhang Z, Fu J, Zhao Y, Kang Q, Han M, Huang C, Guo X, Yan Z, Miao Z, Li J. · 2026-04-01

    open access unreviewed
  5. 5
    Single-cell Transcriptomic Profiling Reveals Diagnostic of T Cell-platelet Aggregates in Peripheral Blood for Coronary Vulnerable Plaques.

    Yao D, Meng P, Huang B, Wu R, Lin Z, Li K, Wu L, Xia P, Liu Q, Wu W, Wang S, Wang Q, Ye F. · 2026-02-04

    open access unreviewed
  6. 6
    Hallmarks of nuclear metabolism: implications for genome integrity, nuclear signaling, and therapeutic targeting.

    Schmidt A, Pfeiffer M, Sdelci S. · 2026-02-02

    cited 3× open access unreviewed
  7. 7
    Intermittent ketogenic diet promotes Treg differentiation and alleviates Crohn's disease via the β-hydroxybutyrate driven AHCY-DNMT1-Foxp3 axis.

    Cheng S, Cheng C, Huang C, Liu C, Xun F, Jiang W, Zhao J, Wang H. · 2026-02-01

    cited 1× unreviewed
  8. 8
    The Nodding syndrome cerebrospinal fluid proteome: a lens into neurodevelopmental failure consistent with environmentally triggered <i>MECP2</i> dysregulation?

    Valdes Angues R, Okot C, Zientek KD, Wilmarth PA, Reddy AP, Odong ALB, Palmer VS, Abwola LK, Ogal E, Okello G… · 2026-01-29

    open access unreviewed
  9. 9
    Efficacy evaluation of the S-adenosylhomocysteine hydrolase inhibitor MSD-914 in rhesus macaques (Macaca Mulatta) challenged with Ebola virus by the intramuscular route.

    Johnston SC, Ginnetti AT, Twenhafel NA, Norris SLW, Chen S, Moore JL, Boyce CW, Frick OM, Dyer DN, Marsh DJ, … · 2026-02-06

    open access unreviewed
  10. 10
    Characterization of Differential GPX4 Essentiality Between Intrahepatic and Extrahepatic Cholangiocarcinoma via Leveraging of a Large-Scale Functional Genomic Screen.

    Lee YR, Seo C, Abdullah M, Baek SH, Lee SJ. · 2025-12-12

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.