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unreviewed

S-adenosylhomocysteine hydrolase (AHCY)

1 reactions · 1 pathways

Cofactors used

H2O

What it does, reaction by reaction

1 reactions

Methionine Cycle / Transmethylation (SAM Cycle, homocysteine) Amino Acid & Nitrogen Metabolism · Cytosol

step 3 Reversible

SAH + H₂O ⇌ homocysteine + adenosine

Converts S-adenosylhomocysteine H2O into Homocysteine Adenosine

› Notes

S-adenosylhomocysteine hydrolase (AHCY) catalyzes a reversible reaction whose in vivo direction is driven toward hydrolysis by rapid removal of homocysteine and adenosine. SAH is a potent competitive inhibitor of many methyltransferases, so its clearance is necessary to preserve methylation potential.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Spatial Coupling of Viral RNA Translation and Replication in Zika Infection.

    Zheng G, Li Y, He X, Tao Y, Zhang J, Zhang L, Chen M, Cai P, Cho WC, Zheng Y, Zhang X. · 2026-09-08

    open access unreviewed
  2. 2
    Ultrasound-Assisted Enhancement of Germinated Sorghum: Multi-Omics Insights into Amino Acid and Carbohydrate Metabolic Regulation.

    Huang Q, Liu Y, Wang Y, Zhao Y, Liu J, Xu T, He Y, Zhang G, Liu H. · 2026-08-19

    open access unreviewed
  3. 3
    The glycine N-methyltransferase amino-terminus regulates folate-dependent feedback inhibition and S-adenosylmethionine homeostasis.

    Kraz I, Mak OW, Hegde S, Lorton BM, Hector H, Broussalian MK, Graff S, Aguilan J, Bonanno J, Eskandari R, Gro… · 2026-08-19

    open access unreviewed
  4. 4
    Molecular Mechanisms Associated with Metabolic Dysfunction: Contributions of Nutritional Genomics.

    Delmicon NE, Franco NDR, Corsi GC, Kim Cho RMK, Vidal HC, Rogero MM. · 2026-07-16

    open access unreviewed
  5. 5
    Sulfur-Containing Amino Acid Homeostasis in the Central Nervous System: From Physiology Regulation to Metal-Induced Neurotoxicity.

    González-Alfonso WL, Vázquez-Cervantes GI, Flores I, Gonsebatt ME, Pérez de la Cruz G, Gómez Manzo S, Salazar… · 2026-07-01

    open access unreviewed
  6. 6
    Ahcy Acts as an Effector of Hnf4a-Driven Super-Enhancer Activation to Alleviate MASLD During Intermittent Fasting.

    Chen H, Zhang S, Deng X, Xie W, Xu F, Shen J, Liang H. · 2026-07-27

    open access unreviewed
  7. 7
    Multi-Omics Profiling of the Scaphoideus titanus Yeast-Like Symbiont Guides the Bioinformatic Discovery of Related Fungal Symbioses in Insects.

    Abbà S, Vallino M, Cicerone A, Cirrincione S, Aiuto B, Galetto L, Rossi M. · 2026-07-01

    open access unreviewed
  8. 8
    Asarinin attenuates ferroptosis resistance by inhibiting the activity of S-adenosyl homocysteine hydrolase in lung cancer.

    Li Z, Wang Y, Huang Z, Wang Z, Guo Z, Xu E, Zheng Y. · 2026-05-13

    unreviewed
  9. 9
    Moderate Methionine Reduction Alleviates Lipopolysaccharide-Induced Stress in Broiler Chickens by Enhancing Antioxidant Pathways.

    Niu J, Dong Y, Du M, Zhang Z, Fu J, Zhao Y, Kang Q, Han M, Huang C, Guo X, Yan Z, Miao Z, Li J. · 2026-04-01

    open access unreviewed
  10. 10
    Single-cell Transcriptomic Profiling Reveals Diagnostic of T Cell-platelet Aggregates in Peripheral Blood for Coronary Vulnerable Plaques.

    Yao D, Meng P, Huang B, Wu R, Lin Z, Li K, Wu L, Xia P, Liu Q, Wu W, Wang S, Wang Q, Ye F. · 2026-02-04

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.