What it does, reaction by reaction
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol
Ribose 5-phosphate → 5-phosphoribosyl-1-pyrophosphate (PRPP)
Converts Ribose-5-phosphate into PRPP
› Notes
Ribose-phosphate pyrophosphokinase (PRPP synthetase) transfers pyrophosphate from ATP to ribose 5-phosphate: ribose 5-phosphate + ATP → PRPP + AMP. Mg2+ and inorganic phosphate are required/activating; this reaction consumes two high-energy phosphate equivalents because ATP is converted to AMP. It is irreversible in vivo and is a major control point that supplies PRPP to both de novo and salvage pathways, but it is not the committed step of purine synthesis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Acquired thiopurine resistance and mismatch repair aberrations in paediatric B-cell acute lymphoblastic leukaemia relapse: A real-world data integrating mutational signatures, clones and clinical thiopurine dosing patterns.
Bhatia P, Sharun S, Palla S, Brady SW, Kirubanandhan S, Ansari S, Singh M, Sreedharanunni S, Das A, Trehan A. · 2026-05-26
unreviewed -
2
Broadening the phenotypic and molecular spectrum of PRS deficiency in females.
Braid T, Scholten S, Yoganathan S, Alsalamah AK, Deschênes D, Deslongchamps G, Goobie S, Heon E, Tein I, Desh… · 2026-04-01
open access unreviewed -
3
The Interplay of Splicing and Metabolism in Cancer.
Voss DM, Cui Y, Klein PS. · 2026-06-20
cited 1× open access unreviewed -
4
Ammonia storm: unmasking a suspected rare proximal urea cycle disorder in adulthood.
Vikhe V, Shaik MH, Khaire P, Patil R, Chakraborty A. · 2026-06-12
unreviewed -
5
Proteome-wide quantification of inositol pyrophosphate-protein interactions.
Richter A, Isern JA, Ruwolt M, Lampe S, Majumdar A, Liu F, Furkert D, Fiedler D. · 2026-06-04
open access unreviewed -
6
Hyperammonemia associated with low doses and concentrations of valproic acid in older adults with neurocognitive disorder.
Coyne S, Das A. · 2026-06-02
open access unreviewed -
7
Single-cell identifies and validates human circulating Treg subtype/state Treg<sup>fci</sup> in non-small cell lung cancer.
Liu X, Liu Y, Duan W, Weng J, Dai H, Liu F, Wang L, Qian M, Zhu B, Wu S, Ye Y, Yuan M, Hong S, Wang M, Cheng … · 2026-06-03
cited 1× open access unreviewed -
8
Integrating CRISPR genome editing with liver organoid and hiPSC-derived microfluidic platforms to model metabolic dysfunction-associated steatotic liver disease.
Oluwasegun AK. · 2026-05-19
open access unreviewed -
9
Uncovering metabolic reprogramming in ovarian and cervical cancers with multi-omics.
Ge Y, Luo Y, Hao B, Zhou Y, Wu R, Liu H, Tang L, Li Y, Li Y, Gong S, Liu H. · 2026-04-22
open access unreviewed -
10
Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion-dependent β-thalassaemia.
Theocharaki K, Delicou S, Ntzoura-Kani A, Simantiris N, Politou M, Komninaka V, Samiotaki M, Zoidakis J, Anto… · 2026-04-09
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.