What it does, reaction by reaction
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol
Ribose 5-phosphate → 5-phosphoribosyl-1-pyrophosphate (PRPP)
Converts Ribose-5-phosphate into PRPP
› Notes
Ribose-phosphate pyrophosphokinase (PRPP synthetase) transfers pyrophosphate from ATP to ribose 5-phosphate: ribose 5-phosphate + ATP → PRPP + AMP. Mg2+ and inorganic phosphate are required/activating; this reaction consumes two high-energy phosphate equivalents because ATP is converted to AMP. It is irreversible in vivo and is a major control point that supplies PRPP to both de novo and salvage pathways, but it is not the committed step of purine synthesis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Neuronal Prps is required for synaptic development and locomotor function in Drosophila melanogaster.
Dang TN, Yoshida H. · 2026-08-17
unreviewed -
2
Proteomic Signatures of Noise-Induced Hearing Loss in the Mouse Cochlea.
Batissoco AC, Alencar-Coutinho D, Ferreira-Scatone AC, Diogo-Cavassana S, Oiticica J, Lezirovitz K, Bento RF. · 2026-10-01
open access unreviewed -
3
Effects of N-carbamylglutamate on down yield and quality and thyroid transcriptome in breeding Huoyan geese.
Wang M, Sun M, Han D, Lei S, Xu H, Peng X, Wang C, Ma W. · 2026-06-10
open access unreviewed -
4
PACS1 syndrome variant alters the proteomic landscape of developing cortical organoids
Gomez-Maqueo X, Rylaarsdam L, Woo A, Schroder A, Rakotomamonjy J, Bossert C, Smith T, Ruiz S, Gilardi J, Klei… · 2026-09-24
open access unreviewed -
5
Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase.
Ko CW, Shin D, Park J, Huh J, Kim Y, Park JW. · 2026-09-30
open access unreviewed -
6
The molecular basis of ADP-ribose pyrophosphorylation by a phage PRPS-like enzyme in NAD+ reconstitution.
Liu M, Ma J, Zhang Q, Xu S, Chen J, Lin E, Wu Y, Li H, Zhou B, Chen L. · 2026-09-01
open access unreviewed -
7
From COPD and asthma to lung cancer: potential candidate genes and their associated biological pathways for the incidence risk of lung cancer.
Arabfard M, Azimzadeh Jamalkandi S, Nobakht M Gh BF. · 2026-07-28
open access unreviewed -
8
Characterization of the metabolome and proteome of stem cell-derived human primordial germ cell-like cells: a multi-omics approach.
Vaz Santos M, Schomakers BV, Ayala ML, Jamali T, van Weeghel M, van Pelt AMM, Mulder CL, Hamer G. · 2026-09-18
open access unreviewed -
9
Characterization of posttranslational modification in metabolic dysfunction-associated steatohepatitis: acetylation, lactylation, and phosphorylation.
Li K, Li Y, Zhang Y, Song S, Pa C, Du C, Yang L, Xue G, Gao H. · 2026-07-31
open access unreviewed -
10
Structural and Functional Siderophore Remodeling by Enzymatic Delipidation.
Herzog E, Ishida K, Molloy EM, Hermenau R, Scherlach K, Hertweck C. · 2026-07-24
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.