What it does, reaction by reaction
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol
Ribose 5-phosphate → 5-phosphoribosyl-1-pyrophosphate (PRPP)
Converts Ribose-5-phosphate into PRPP
› Notes
Ribose-phosphate pyrophosphokinase (PRPP synthetase) transfers pyrophosphate from ATP to ribose 5-phosphate: ribose 5-phosphate + ATP → PRPP + AMP. Mg2+ and inorganic phosphate are required/activating; this reaction consumes two high-energy phosphate equivalents because ATP is converted to AMP. It is irreversible in vivo and is a major control point that supplies PRPP to both de novo and salvage pathways, but it is not the committed step of purine synthesis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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