Purine nucleoside phosphorylase (PNP)
Cofactors used
Clinical / pharmacological. PNP deficiency: T-cell immunodeficiency
What it does, reaction by reaction
Purine Degradation (to Uric Acid) Nucleotide Metabolism · Cytosol
Inosine → hypoxanthine
Converts Inosine into Hypoxanthine
› Notes
PNP catalyzes inosine + Pi ⇌ hypoxanthine + ribose 1-phosphate. In catabolic tissues, the reaction commonly proceeds toward free hypoxanthine.
Guanosine → guanine
Converts Guanosine into Guanine
› Notes
PNP catalyzes guanosine + Pi ⇌ guanine + ribose 1-phosphate.
Purine Salvage Pathway Nucleotide Metabolism · Cytosol
Inosine → hypoxanthine + ribose 1-phosphate
Converts Inosine into Hypoxanthine Ribose-1-phosphate
› Notes
Purine nucleoside phosphorylase (PNP) catalyzes inosine + Pi ⇌ hypoxanthine + ribose 1-phosphate. Although this reaction is reversible and is often viewed as degradative, the liberated hypoxanthine can immediately enter the HGPRT reaction in an operational salvage sequence.
Guanosine → guanine + ribose 1-phosphate
Converts Guanosine into Guanine Ribose-1-phosphate
› Notes
PNP catalyzes guanosine + Pi ⇌ guanine + ribose 1-phosphate. Guanine can then be salvaged by HGPRT; direction in vivo depends on substrate and phosphate concentrations.
Showing all 4 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
A streamlined analytical strategy combining plant metabolomics and interpretable machine learning for detecting homologous adulteration in Panax notoginseng powder.
Zhou H, Zhang Y, Yan J, Zeng J, Qiao M, Chen X, Sun L, Zhang E, Chen M. · 2026-07-09
unreviewed -
2
Triptolide loaded cerium oxide nanozyme based oral nanoplatform for targeted colitis therapy.
Lu J, Chen Y, Ding W, Zheng S, Yang L, Wang Y, Ji Q, Qi C, Gao F. · 2026-06-18
unreviewed -
3
Synergistic application of taurine and spermidine enhances wheat tolerance to neodymium stress through redox homeostasis, metabolic adjustment, and nutrient regulation.
Iqbal R, Mehmood H, Majeed A, Murtaza G, Rebouh NY, Alotaibi MS, Alotaibi SS, Ullah S, Huseynova A, Ali S. · 2026-06-15
open access unreviewed -
4
High-throughput identification of bacterial β-glucuronidase inhibitors using machine learning.
Zhang B, Yue H, Skalse A, Sangfuang N, Shorthouse D, Gaisford S, Basit AW. · 2026-06-05
open access unreviewed -
5
Two-step bioconversion of pyridoxal 5'-phosphate from pyridoxine through cofactor regeneration and pyridoxine 5'-phosphate oxidase evolution.
Yang X, Lu B, Wang M, Chen Y, Lu X, Tao Y, Huang J, Ke C. · 2026-04-06
open access unreviewed -
6
Efficient whole-cell biotransformation for gastrodin production via glycosyltransferase engineering and process optimization.
Wang X, Zhang J, Li T, Wang F, Wang Z, Li X. · 2026-04-06
open access unreviewed -
7
<i>Fusobacterium nucleatum</i> plays a pathogenic role in a murine model of irritable bowel syndrome by modulating intestinal purine metabolism and promoting mast cell activation.
Hou S, Ning T, Liu S, Yang X, Ye H, Zhou Y, Wang C, Zhu J, Lu S, Zhang N, Zhu S. · 2026-01-28
open access unreviewed -
8
Porcine serum maltase-glucoamylase: structure, kinetics, and inhibition.
Watanabe K, Tagami T, Biwa C, Kawasaki M, Adachi N, Moriya T, Senda T, Okuyama M. · 2026-01-14
open access unreviewed -
9
Bioengineered titanium implants functionalized with aptamer-valproic acid conjugates orchestrate macrophage programming and mesenchymal stem cell homing for improved osseointegration.
Sun D, Zhou Q, Guo X, Shi H, Wang X, Li X, Zheng Z, Zhong L, Cao S, Shan R, Su Z, Ma C, Zhao L. · 2026-06-06
open access unreviewed -
10
Comprehensive analysis of the association between perfluorooctanoic acid exposure and osteosarcoma progression.
Dong Y, Zheng J, Dong X, Lv Y, Xu Z, Ye C, Zhu S, Dong H, Lv Y. · 2026-07-16
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.