Protoporphyrinogen oxidase (PPOX)
Cofactors used
What it does, reaction by reaction
Heme Biosynthesis (Porphyrin Pathway) Amino Acid & Nitrogen Metabolism · Mitochondrion + cytosol
Protoporphyrinogen IX + 3 O₂ → protoporphyrin IX + 3 H₂O₂ (net oxidation)
Converts Protoporphyrinogen IX O2 into Protoporphyrin IX H2O2
› Notes
Protoporphyrinogen oxidase (PPOX), a FAD-dependent enzyme associated with the inner mitochondrial membrane, oxidizes the reduced porphyrinogen to the conjugated porphyrin. Molecular oxygen is the terminal electron acceptor; this step is essentially irreversible.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Discovery of ALA-hydroxypyridinone hybrids: novel strategies for photodynamic therapy against superficial tumours.
Jiang X, Feng M, Niu X, Wang S, Sun Y, Chen W, Bai R. · 2026-07-08
open access unreviewed -
2
Intravenous hemin for prevention of frequent attacks of acute hepatic porphyria - a double-blind placebo controlled pilot study.
Moghe A, Kormos-Hallberg C, Villasante-Tezanos A, Anderson KE. · 2026-09-24
unreviewed -
3
A Tarui Disease Phenotype with Compensated Hemolysis and a Homozygous <i>PFKM</i> Variant of Uncertain Significance Mimicking Chronic Myelomonocytic Leukemia.
Neculcea AC, Aanicai R, Massoto B, Nistor RI, Fierbințeanu-Braticevici C, Mambet C, Mititelu A, Neagu AM, Par… · 2026-09-07
open access unreviewed -
4
Oxidative stress impacts carbon metabolism and induces upregulation of redox enzymes andsmall secreted proteins in the wood-decay fungus.
Österman-Udd J, Kiviniemi EA, Simojoki A, Wahlsten M, Lundell T. · 2026-09-11
open access unreviewed -
5
The Discovery of GSK3227634: A Potent Inhaled Inhibitor of the KEAP1/NRF2 Protein-Protein Interaction for the Treatment of Chronic Obstructive Pulmonary Disease.
Callahan JF, Davies TG, Bantscheff M, Bedard S, Boehm J, Booth-Genthe C, Concha N, Copley R, Davis A, Davis R… · 2026-09-01
open access unreviewed - 6
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7
Alleviation of CO<sub>2</sub>-Induced Reductions in Tomato Photosynthesis Under Deficit Irrigation by Purple Nonsulfur Photosynthetic Bacteria.
Du B, Kang J, Shukla MK, Du T. · 2026-09-01
unreviewed -
8
High frequency of the PPOX p.Arg168His pathogenic variant among Brazilian patients with variegate porphyria.
Paiva MA, Covaleski APPM, Silva TO, Bittar-Braune C, Franz C, Holanda Mendonça R, Moreno CAM, Zanoteli E, Mac… · 2026-08-04
unreviewed -
9
Challenges in Porphyria diagnosis and management: When variegate Porphyria meets HIV.
Varela LS, Melito VA, Caballero FA, Guolo M, Goñi V, Baccaro F, Agosta M, Pasman M, Pachioli V, Tomassi VL, B… · 2026-07-30
unreviewed -
10
Patient-centered and coordinated therapy with RNA interference-based givosiran for acute hepatic porphyria: real-life experience for an ultra-rare disease from Romania.
Bancos A, Jitaru C, Uhl A, Roibu D, Santa M, Nistor M, Ivancuta A, Moldovan CS, Dima D, Puiu M, Tomuleasa C. · 2026-07-31
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.