unreviewed

Phosphoribosylamine--glycine ligase (GAR synthetase)

1 reactions · 1 pathways

Cofactors used

ATP Pi

What it does, reaction by reaction

1 reactions

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol

step 3 Irreversible/directional

5-PRA → glycinamide ribonucleotide (GAR)

Converts 5-Phosphoribosylamine into Glycinamide ribonucleotide (GAR)

› Notes

Phosphoribosylamine--glycine ligase (GAR synthetase) catalyzes 5-PRA + glycine + ATP → GAR + ADP + Pi. Mg2+ is required; glycine contributes C4, C5, and N7 of the future purine ring.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

Refresh

Europe PMC · fetched just now · sorted by publication date

1
Complexomics study of two Helicobacter pylori strains of two pathological origins: potential targets for vaccine development and new insight in bacteria metabolism.
Bernarde C, Lehours P, Lasserre JP, Castroviejo M, Bonneu M, Mégraud F, Ménard A. · 2010-07-07

cited 18× unreviewed
2
Something old, something new, something borrowed; how the thermoacidophilic archaeon Sulfolobus solfataricus responds to oxidative stress.
Maaty WS, Wiedenheft B, Tarlykov P, Schaff N, Heinemann J, Robison-Cox J, Valenzuela J, Dougherty A, Blum P, … · 2009-09-16

cited 56× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.