Acetyl-CoA carboxylase (ACC1)
Cofactors used
Clinical / pharmacological. Biotin-dependent; inhibited by AMPK; ACC inhibitors studied in NASH/obesity
What it does, reaction by reaction
Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol
Acetyl-CoA + HCO3− + ATP → malonyl-CoA + ADP + Pi
Converts Acetyl-CoA HCO3- ATP into Malonyl-CoA ADP Pi
› Notes
Acetyl-CoA carboxylase (ACC1) uses covalently bound biotin, ATP, and bicarbonate to carboxylate acetyl-CoA. This is the committed, rate-limiting, and irreversible regulatory step of cytosolic fatty-acid synthesis. The added carbon is later released as CO2 and thereby drives chain elongation.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Fatty Acid Synthesis (De Novo Lipogenesis)
Citrate; dephosphorylation; insulin-induced expression
Palmitoyl-CoA and other long-chain acyl-CoAs; phosphorylation by AMPK and PKA
Insulin activates by dephosphorylation and induces transcription through SREBP-1c; glucagon/epinephrine inhibit through phosphorylation in liver/adipose
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Microbiota-liver axis and host transcriptomic mechanisms underlying the anti-obesity effects of Bifidobacterium animalis DPU-MWFBA in early-life overfeeding.
Gao Z, Zhao B, Mu G, Nie H, Wu X. · 2026-06-27
unreviewed -
2
Multi-omics characterization of glucose-lipid metabolic remodeling associated with Gymnema sylvestre (Retz.) R.Br. ex Sm. treatment in a type 2 diabetic mouse model.
Zeng Z, Liu Y, Xiao G, Jia C, Wu M, Li Y, Jiang J, Zhang J, Xu A, Bi X. · 2026-06-20
unreviewed -
3
Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.
Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01
open access unreviewed -
4
MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming.
Kisielewska M, Suwała S, Drąg-Zalesińska M, Rembiałkowska N. · 2026-06-15
open access unreviewed -
5
Metformin counteracts lipid accumulation and cell proliferation in hepatocellular carcinoma via regulating METTL3-mediated m<sup>6</sup>A methylation.
Qi Y, Chen C, Dai Y, Wang Z, Liu X, Guo C, Wang M, Hu Z, Di H. · 2026-05-03
unreviewed -
6
Integrative metabolomic and transcriptomic analysis reveals stage-specific shifts in hepatic lipid metabolism of broiler chickens.
Li J, Xu Y, Ren P, Xiong X, Qiu M, Yu C, Liu Y, Yang C. · 2026-02-03
open access unreviewed -
7
Multi-omics dissection of metabolic hijacking: Infectious bronchitis virus orchestrates lipid-centric replication through PPAR-TGF-β crosstalk.
Yan K, Wang X, Bo Z, Zhang C, Guo M, Zhang X, Wu Y. · 2026-01-28
cited 1× open access unreviewed -
8
Metabolomic profiling of neat uterine luminal fluid in cows: local enrichment and nutritional modulation.
Sagheer M, Hoorn QA, Maldonado MB, Schalich KM, Ashrafi N, A Mimi R, Graham SF, Selvaraj V, Hansen PJ. · 2026-01-07
cited 3× open access unreviewed -
9
Reversed cortico-medullary differentiation in kidneys on fetal magnetic resonance imaging - a case series.
Bekiesinska-Figatowska M, Madzik J, Ring M, Skorka A, Smyk M, Obersztyn E. · 2025-08-21
cited 1× open access unreviewed -
10
Bacteroides thetaiotaomicron and Bacteroides ovatus for the treatment of MAFLD: A comparative study of individual and combined effects.
Li X, Zhou G, Sun C, She R, Feng W, Fu X, Wu S, Li D, Pan L, Liu X, Xiong X. · 2026-04-12
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.