Phospholipase D
What it does, reaction by reaction
Phospholipid Degradation (Phospholipases) Lipid Metabolism · Membranes, lysosome, plasma
Phosphatidylcholine + H2O -> phosphatidic acid + choline
Converts Phosphatidylcholine H2O into Phosphatidic acid Choline
› Notes
Cleaves distal to the phosphate, releasing the head-group alcohol.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Beyond spherical vesicles: morphological diversity of extracellular vesicles in health and disease.
Velázquez-Cervantes MA, Fierro NA, Lozano-Hernández R, Carrero JC. · 2026-05-04
open access unreviewed -
2
<i><b>Limosilactobacillus mucosae</b></i> <b>attenuates hyperlipidemic periodontitis via the gut-oral axis</b>.
Xu J, Han Z, Xue Q, Wang H, Song J, Li Y, Zhang Y, Wang D, Hu M. · 2026-01-20
open access unreviewed -
3
Targeting CXCL8 in post-traumatic stress disorder and Alzheimer's disease: insights from cross-disorder molecular analysis.
Liao D, Zhang M, Yang Q, Li T, Cao Z, Liu D, Zhang Z, Li X, Tian Z, Li X, Luo P. · 2026-01-09
cited 1× open access unreviewed -
4
8-hydroxyquinoline derivatives as powerful, versatile, and sensitive fluorescent probes to assay phospholipase D.
Malcles L, Comte A, Lusseau J, Grand L, Soulère L, Mouhand A, Abousalham A, Noiriel A. · 2026-05-18
unreviewed -
5
Spatiotemporal regulation of neutrophil-mediated immune cascades via engineered PEEK surfaces restores osseointegration in diabetes.
Tan J, Yang D, Qin L, Chen Z, Xu Z, Wei C, Chen J, Huang Y, Yang D, Fang Y, Tang M, Wen H, Yi W, Gao A, Zhang… · 2026-05-21
open access unreviewed -
6
Reference values for the alcohol biomarker phosphatidylethanol (PEth) in the Belgian population: Insights from a nationwide microsampling study.
Vandenbroucke K, Van Uytfanghe K, Heughebaert L, Berger N, De Boosere E, Stove CP. · 2026-05-23
open access unreviewed -
7
Piezo ion channels in the digestive system: Mechanotransduction pathways and therapeutic targeting strategies.
Yan X, Zeng W, Ma P, Yao J, Ma T, Li Y. · 2025-11-07
open access unreviewed -
8
Crystal Structure of PLD From Arcanobacterium haemolyticum Identifies a Novel Class IIa-α Variant With Unusual Thermostability.
Gismene C, Alvares DS, Doherty DZ, Schemczssen-Graeff Z, de Almeida Passos Cerbino LE, Ziem Nascimento AF, Ra… · 2026-05-26
unreviewed -
9
Venom characterization and structural insights into phospholipase D isoforms from the spider Loxosceles aff. variegata.
Silva-Araújo AL, Silva-Magalhães R, Peres-Damásio P, Pereira EHT, de Oliveira Souza R, Varela LSDRN, Ribeiro … · 2026-04-29
unreviewed -
10
x-Ray Structure of Streptomyces avermitilis Phospholipase D Reveals a Ca<sup>2+</sup>-Stabilized Expanded Active-Site Cleft Adapted for Phospholipid Binding.
Yasutake Y, Hirata T, Nomura S, Konishi K, Yoneda K, Sakasegawa SI, Sakuraba H. · 2026-04-30
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.