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MS
unreviewed

Phospholipase D

1 reactions · 1 pathways

What it does, reaction by reaction

1 reactions

Phospholipid Degradation (Phospholipases) Lipid Metabolism · Membranes, lysosome, plasma

step 4 Irreversible/directional

Phosphatidylcholine + H2O -> phosphatidic acid + choline

Converts Phosphatidylcholine H2O into Phosphatidic acid Choline

Notes

Cleaves distal to the phosphate, releasing the head-group alcohol.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

Europe PMC · fetched just now · sorted by publication date

  1. 1
    Beyond spherical vesicles: morphological diversity of extracellular vesicles in health and disease.

    Velázquez-Cervantes MA, Fierro NA, Lozano-Hernández R, Carrero JC. · 2026-05-04

    open access unreviewed
  2. 2
    <i><b>Limosilactobacillus mucosae</b></i> <b>attenuates hyperlipidemic periodontitis via the gut-oral axis</b>.

    Xu J, Han Z, Xue Q, Wang H, Song J, Li Y, Zhang Y, Wang D, Hu M. · 2026-01-20

    open access unreviewed
  3. 3
    Targeting CXCL8 in post-traumatic stress disorder and Alzheimer's disease: insights from cross-disorder molecular analysis.

    Liao D, Zhang M, Yang Q, Li T, Cao Z, Liu D, Zhang Z, Li X, Tian Z, Li X, Luo P. · 2026-01-09

    cited 1× open access unreviewed
  4. 4
    8-hydroxyquinoline derivatives as powerful, versatile, and sensitive fluorescent probes to assay phospholipase D.

    Malcles L, Comte A, Lusseau J, Grand L, Soulère L, Mouhand A, Abousalham A, Noiriel A. · 2026-05-18

    unreviewed
  5. 5
    Spatiotemporal regulation of neutrophil-mediated immune cascades via engineered PEEK surfaces restores osseointegration in diabetes.

    Tan J, Yang D, Qin L, Chen Z, Xu Z, Wei C, Chen J, Huang Y, Yang D, Fang Y, Tang M, Wen H, Yi W, Gao A, Zhang… · 2026-05-21

    open access unreviewed
  6. 6
    Reference values for the alcohol biomarker phosphatidylethanol (PEth) in the Belgian population: Insights from a nationwide microsampling study.

    Vandenbroucke K, Van Uytfanghe K, Heughebaert L, Berger N, De Boosere E, Stove CP. · 2026-05-23

    open access unreviewed
  7. 7
    Piezo ion channels in the digestive system: Mechanotransduction pathways and therapeutic targeting strategies.

    Yan X, Zeng W, Ma P, Yao J, Ma T, Li Y. · 2025-11-07

    open access unreviewed
  8. 8
    Crystal Structure of PLD From Arcanobacterium haemolyticum Identifies a Novel Class IIa-α Variant With Unusual Thermostability.

    Gismene C, Alvares DS, Doherty DZ, Schemczssen-Graeff Z, de Almeida Passos Cerbino LE, Ziem Nascimento AF, Ra… · 2026-05-26

    unreviewed
  9. 9
    Venom characterization and structural insights into phospholipase D isoforms from the spider Loxosceles aff. variegata.

    Silva-Araújo AL, Silva-Magalhães R, Peres-Damásio P, Pereira EHT, de Oliveira Souza R, Varela LSDRN, Ribeiro … · 2026-04-29

    unreviewed
  10. 10

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.