What it does, reaction by reaction
Phospholipid Degradation (Phospholipases) Lipid Metabolism · Membranes, lysosome, plasma
PIP2 -> diacylglycerol + inositol-1,4,5-trisphosphate
Converts PIP2 into Diacylglycerol Inositol-1,4,5-trisphosphate
› Notes
Cleaves the glycerophosphate bond; generates the two second messengers of the Gq pathway.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Impaired membrane lipids in ischemic stroke: a key player in inflammation and thrombosis.
Wang Q, Wang D, Gao Y, Jiang J, Li M, Li S, Hu X, Wang J, Wang T, Zhang J, Feng L, Quan C, Zhang P, Zheng L, … · 2025-05-28
cited 9× open access unreviewed -
2
Effects of Deoxynivalenol and Its Acetylated Derivatives on Lipid Metabolism in Human Normal Hepatocytes.
Ma Z, He Y, Li Y, Wang Q, Fang M, Yang Q, Gong Z, Xu L. · 2024-06-26
cited 5× open access unreviewed -
3
Integrated Omics Analysis Uncovers the Culprit behind Exacerbated Atopic Dermatitis in a Diet-Induced Obesity Model.
Ahn YM, Jung J, Lee SM. · 2024-04-09
cited 4× open access unreviewed -
4
Mining key circRNA-associated-ceRNA networks for milk fat metabolism in cows with varying milk fat percentages.
Feng X, Tong L, Ma L, Mu T, Yu B, Ma R, Li J, Wang C, Zhang J, Gu Y. · 2024-04-01
cited 4× open access unreviewed -
5
DNA methylation status of the SPHK1 and LTB genes underlies the clinicopathological diversity of non-alcoholic steatohepatitis-related hepatocellular carcinomas.
Tsuda N, Tian Y, Fujimoto M, Kuramoto J, Makiuchi S, Ojima H, Gotoh M, Hiraoka N, Yoshida T, Kanai Y, Arai E. · 2022-11-08
cited 2× open access unreviewed -
6
Gene expression of the endocannabinoid system in endometrium through menstrual cycle.
Tanaka K, Amoako AA, Mortlock S, Rogers PAW, Holdsworth-Carson SJ, Donoghue JF, Teh WT, Montgomery GW, McKinn… · 2022-06-07
cited 11× open access unreviewed -
7
Integrated analysis of mRNA and long noncoding RNA profiles in peripheral blood mononuclear cells of patients with bronchial asthma.
Cui H, Duan R, Niu H, Yu T, Huang K, Chen C, Hao K, Yang T, Wang C. · 2022-05-02
cited 2× open access unreviewed -
8
CXCR2 inhibition enables NASH-HCC immunotherapy.
Leslie J, Mackey JBG, Jamieson T, Ramon-Gil E, Drake TM, Fercoq F, Clark W, Gilroy K, Hedley A, Nixon C, Luli… · 2022-04-27
cited 171× open access unreviewed -
9
Systematic analysis of the expression and prognostic value of ITPR1 and correlation with tumor infiltrating immune cells in breast cancer.
Han B, Zhen F, Zheng XS, Hu J, Chen XS. · 2022-03-21
cited 10× open access unreviewed -
10
The Prominent Role of miR-942 in Carcinogenesis of Tumors.
Yadegar N, Dadashi Z, Shams K, Mohammadi M, Abyar M, Rafat M. · 2022-07-29
cited 10× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.