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rate-limiting unreviewed

Phospholipase A2 (cPLA2/sPLA2)

1 reactions · 1 pathways

Cofactors used

Ca2+

Clinical / pharmacological. Suppressed indirectly by corticosteroids (annexin/lipocortin)

What it does, reaction by reaction

1 reactions

Phospholipid Degradation (Phospholipases) Lipid Metabolism · Membranes, lysosome, plasma

step 2 Irreversible/directional rate-limiting

Phospholipid -> arachidonate (sn-2) + lysophospholipid

Converts Phospholipid into Arachidonate (sn-2) Lysophospholipid

› Notes

Cleaves the sn-2 bond and is the rate-limiting release of arachidonic acid for eicosanoid synthesis; inhibited indirectly by glucocorticoid-induced lipocortin/annexin.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Lipid metabolism in hepatopancreas and ovaries of the mud crab Scylla paramamosain during vitellogenesis.

    Zeng X, Huang C, Deng Z, Xiao Y, Zou P, Wang Y. · 2026-06-01

    unreviewed
  2. 2
    Multi-omics integration reveals convergent extracellular matrix remodelling and lipid metabolic reprogramming as central axes of adipocyte differentiation from mouse embryonic stem cells.

    Al-Sayegh M, Khalili M, Alzaabi M, Sultana M, Ali L, Ali M, El-Hadidi M. · 2026-06-02

    open access unreviewed
  3. 3
    Melatonin-enabled omics: understanding plant responses to single and combined abiotic stresses for climate-smart agriculture.

    Raza A, Li Y, Charagh S, Guo C, Zhao M, Hu Z. · 2026-01-27

    cited 9× open access unreviewed
  4. 4
    The Phospholipase A<sub>2</sub> Superfamily in Health and Disease: From Lipid Signaling to Inflammation, Cancer, and Neurodegeneration.

    Sikder MM, Labony SA. · 2026-04-10

    open access unreviewed
  5. 5
    The genomic origins and evolutionary path to a key innovation in the world's most venomous snakes.

    van Thiel J, Dowell NL, Smith CF, Sanchez EE, Carroll SB. · 2026-09-04

    cited 1× open access unreviewed
  6. 6
    Melatonin and Brassinolide Enhance Cold Tolerance in <i>Osmanthus fragrans</i>: Insights from Integrated Physiological and Multi-Omics Analyses.

    Xia H, Huang W, Zou J, Chen H, Cai X, Yang J, Li Z, Zeng X, Wu Y, Zhang Y. · 2026-08-06

    open access unreviewed
  7. 7
    Dynamics of Functional Traits and Molecular Regulation in the Vascular Cambium Across Different Ages of <i>Styphnolobium japonicum</i>.

    Gao X, He X, Wu H, Li S, Yin S, Xue Z, Liang Y, Cao H, Wang R, Zhang B, Hao J, Gao R. · 2026-07-29

    open access unreviewed
  8. 8
    Selenium nanoparticles and glutathione synergistically enhance salt tolerance in soybean via the jasmonic acid pathway and arbutin-regulated rhizosphere microbiota.

    Chen Y, Zhao S, Ma X, Ling L, Du P, Liu X, Yao Y, Ma Q, Cheng Y, Wang Y, Wei J, Nian H, Lian T. · 2026-01-15

    cited 1× open access unreviewed
  9. 9
    Effects of different dietary methionine and cysteine ratios on growth performance and intestinal development of broilers from brain-gut peptide secretion perspective.

    Chen Z, Zhao Y, Chai H, Zhao D, Xu L, Teng T. · 2026-02-06

    open access unreviewed
  10. 10
    Phosphorus Acquisition Strategies Among Phytoplankton and Free-Living Bacterial Communities in the Baltic Proper.

    Thomas M, Hanna F, Elin L, Daniel L, Jarone P, Catherine L. · 2026-04-01

    cited 2× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.