Phospholipase A2 (cPLA2/sPLA2)
Cofactors used
Clinical / pharmacological. Suppressed indirectly by corticosteroids (annexin/lipocortin)
What it does, reaction by reaction
Phospholipid Degradation (Phospholipases) Lipid Metabolism · Membranes, lysosome, plasma
Phospholipid -> arachidonate (sn-2) + lysophospholipid
Converts Phospholipid into Arachidonate (sn-2) Lysophospholipid
› Notes
Cleaves the sn-2 bond and is the rate-limiting release of arachidonic acid for eicosanoid synthesis; inhibited indirectly by glucocorticoid-induced lipocortin/annexin.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Multi-omics integration reveals convergent extracellular matrix remodelling and lipid metabolic reprogramming as central axes of adipocyte differentiation from mouse embryonic stem cells.
Al-Sayegh M, Khalili M, Alzaabi M, Sultana M, Ali L, Ali M, El-Hadidi M. · 2026-06-02
open access unreviewed -
2
Melatonin-enabled omics: understanding plant responses to single and combined abiotic stresses for climate-smart agriculture.
Raza A, Li Y, Charagh S, Guo C, Zhao M, Hu Z. · 2026-01-27
cited 5× open access unreviewed -
3
Lipid metabolism in hepatopancreas and ovaries of the mud crab Scylla paramamosain during vitellogenesis.
Zeng X, Huang C, Deng Z, Xiao Y, Zou P, Wang Y. · 2026-06-01
unreviewed -
4
Selenium nanoparticles and glutathione synergistically enhance salt tolerance in soybean via the jasmonic acid pathway and arbutin-regulated rhizosphere microbiota.
Chen Y, Zhao S, Ma X, Ling L, Du P, Liu X, Yao Y, Ma Q, Cheng Y, Wang Y, Wei J, Nian H, Lian T. · 2026-01-15
open access unreviewed -
5
Effects of different dietary methionine and cysteine ratios on growth performance and intestinal development of broilers from brain-gut peptide secretion perspective.
Chen Z, Zhao Y, Chai H, Zhao D, Xu L, Teng T. · 2026-02-06
open access unreviewed -
6
Phosphorus Acquisition Strategies Among Phytoplankton and Free-Living Bacterial Communities in the Baltic Proper.
Thomas M, Hanna F, Elin L, Daniel L, Jarone P, Catherine L. · 2026-04-01
open access unreviewed -
7
The molecular mechanism of the α-linolenic acid metabolism pathway in rice in response to Cd stress.
Lin C, Wang Y, Qiu L, Lin Q, Zhang R, Xie Q, Hu H, Xue Y, Liu Y. · 2026-03-12
open access unreviewed -
8
Ability of the Chinese herbal residue to alleviate short-distance transportation stress in sheep through the remodeling of the rumen microbiome-metabolism axis.
Li J, Ren J, Xu J, He J, Xu J, Yin Q, Yao J, Wu S. · 2026-03-01
open access unreviewed -
9
The Microbiota Shapes Central Nervous System Myelination in Early Life.
Lynch CMK, Knox EG, Soong D, Bastiaanssen TFS, Trontti K, Tofani GSS, Ivaschuk S, Collins MK, Arafa D, Nagpal… · 2026-01-18
open access unreviewed -
10
Analyzing the transcriptomic diversity in isolated mature adipocytes from the major fat depots in rainbow trout (Oncorhynchus mykiss).
Rosell-Moll E, Capilla E, Navarro I, Garcia de la Serrana D. · 2026-02-11
open access unreviewed
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