What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
3-Phosphoglycerate + ATP → 1,3-bisphosphoglycerate + ADP
Converts 3-Phosphoglycerate ATP into 1,3-Bisphosphoglycerate ADP
› Notes
Phosphoglycerate kinase requires ATP and Mg2+. This is the reverse of glycolytic substrate-level phosphorylation and occurs twice for each glucose produced.
Glycolysis Carbohydrate Metabolism · Cytosol
1,3-Bisphosphoglycerate + ADP → 3-phosphoglycerate + ATP
Converts 1,3-Bisphosphoglycerate ADP into 3-Phosphoglycerate ATP
› Notes
Phosphoglycerate kinase requires Mg2+ and catalyzes reversible substrate-level phosphorylation. Occurring twice per glucose, this first payoff reaction produces two ATP and thereby repays the two ATP invested in steps 1 and 3.
Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration · Cytosol
1,3-Bisphosphoglycerate + ADP ⇌ 3-phosphoglycerate + ATP
Converts 1,3-Bisphosphoglycerate ADP into 3-Phosphoglycerate ATP
› Notes
Required cofactors: ADP and Mg2+. This reversible substrate-level phosphorylation step produces the first ATP-generating reaction of glycolysis; because it occurs twice per glucose, it replaces the two ATP invested earlier.
Showing all 3 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
The RNA binding protein ZFP36L2 displays tissue-selective mRNA targeting in mice.
Stephenson GS, Fleifel D, Cook JG, Laederach A, Ramos SBV. · 2026-06-21
open access unreviewed -
2
Research progress of ferroptosis in gynecological diseases.
Chen W, Zhou W, Liu S. · 2026-06-19
open access unreviewed -
3
The regulatory roles of non-coding RNAs in aerobic glycolysis and therapeutic potential in pancreatic ductal adenocarcinoma.
Fan Y, Tang X, Li S, Liu S, Fang Y, Sun X, Xue Z, Niu H, Chen Y, Dai C, Ling R. · 2026-06-09
open access unreviewed -
4
The double-edged nature of antibody bivalency: mathematical and experimental analysis of cell surface antigen occupancy and opsonization.
Heirene L, Lodge J, Fedorova M, Gauntlett R, Cordy J, Rattray Z, Byrne H, Gaffney E, Yates JWT. · 2026-06-03
open access unreviewed -
5
Beyond spherical vesicles: morphological diversity of extracellular vesicles in health and disease.
Velázquez-Cervantes MA, Fierro NA, Lozano-Hernández R, Carrero JC. · 2026-05-04
open access unreviewed -
6
Immunotherapy impact of macrophage glycosylation on cholangiocarcinoma and its prognostic and immune microenvironment significance.
Xu Y, Xu X, Xu Y, Duan J. · 2026-03-09
open access unreviewed -
7
Re-engineering insulin for oral delivery: structural modifications, advanced formulation strategies, and future directions.
Zheng Y, Fang X, Gao J. · 2026-02-05
open access unreviewed -
8
Bacterial cell envelope components of gut commensals: effects in host-microbe interaction.
Vilela Rodrigues T, Lima de Jesus L, Langella P, de Castro Soares S, Jan G, Ariston de Carvalho Azevedo V, Ch… · 2026-01-30
cited 1× open access unreviewed -
9
RGG-motif protein Scd6 affects oxidative stress response by regulating cytosolic caTalase T1 (Ctt1).
Tiwari S, Togra C, Sj S, Rajyaguru PI. · 2026-01-09
cited 1× open access unreviewed -
10
Genome-wide Identification of conditionally essential genes supporting <i>Streptococcus suis</i> growth in serum and cerebrospinal fluid.
Juanpere-Borras M, Zhao T, Boekhorst J, Fernandez-Ciruelos B, Sanyal R, Arifa N, Wagenaar T, van Baarlen P, W… · 2025-12-15
cited 1× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.