What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
3-Phosphoglycerate + ATP → 1,3-bisphosphoglycerate + ADP
Converts 3-Phosphoglycerate ATP into 1,3-Bisphosphoglycerate ADP
› Notes
Phosphoglycerate kinase requires ATP and Mg2+. This is the reverse of glycolytic substrate-level phosphorylation and occurs twice for each glucose produced.
Glycolysis Carbohydrate Metabolism · Cytosol
1,3-Bisphosphoglycerate + ADP → 3-phosphoglycerate + ATP
Converts 1,3-Bisphosphoglycerate ADP into 3-Phosphoglycerate ATP
› Notes
Phosphoglycerate kinase requires Mg2+ and catalyzes reversible substrate-level phosphorylation. Occurring twice per glucose, this first payoff reaction produces two ATP and thereby repays the two ATP invested in steps 1 and 3.
Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration · Cytosol
1,3-Bisphosphoglycerate + ADP ⇌ 3-phosphoglycerate + ATP
Converts 1,3-Bisphosphoglycerate ADP into 3-Phosphoglycerate ATP
› Notes
Required cofactors: ADP and Mg2+. This reversible substrate-level phosphorylation step produces the first ATP-generating reaction of glycolysis; because it occurs twice per glucose, it replaces the two ATP invested earlier.
Showing all 3 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Characterization of two key cytochrome P450 enzymes in <i>Isodon amethystoides</i> and <i>de novo</i> production of 3α,15β-dihydroxy-<i>ent-</i>kaurene in yeast.
Chen Y, Song X, Wang Y, Han Y, Xia M, Yuan S, Ma Y, Wang J, Ma Q, Liu S, Su P, Huang L. · 2026-08-27
open access unreviewed -
2
Systematic evaluation of the DNA repair machinery facilitated the development of efficient genome editing tools for the red yeast <i>Rhodotorula toruloides</i>.
Chen Q, Lyu L, Wang S, Zhao ZK. · 2026-08-06
open access unreviewed -
3
Dismantling the eDNA-mediated H<sub>2</sub>S barrier with biohybrids against refractory biofilm infections.
Yin M, Su M, Yi J, Ren Y, Zhang Y, Wu Q, Yang C, Xiao S, Gao C, Tang R, Cheng B, Xia J. · 2026-09-15
open access unreviewed -
4
Going high-throughput: Dynamic conformations and interactions <i>in vivo</i>.
Gong Z, Zhao Q, Sun M, Zhang B, Zhang X, Zhang L, Zhang Y, Liu M. · 2026-08-04
open access unreviewed -
5
Mining and engineering of active <i>PB</i> transposons in <i>Hymenoptera</i>.
Wang B, Gao B, Wang Q, Xiang K, Li M, Yang N, Song C. · 2026-07-24
open access unreviewed -
6
Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.
Xiao W, Tan D, Zeng W, Nie X, Wang M. · 2026-01-28
open access unreviewed -
7
An adhesive hydrogel enabling spatiotemporal delivery of umbilical cord exosomes for scarless skin regeneration through immunomodulation and ECM remodeling.
Zhang Y, Xie J, Li J, Li F, Ci Z, Wang J, Hua Y, Wang D, Zhou G, Huo Y. · 2026-08-27
open access unreviewed -
8
Metabolic engineering of <i>Escherichia coli</i> based on adaptive evolution and omics technology for highly efficient l-valine production under oxygen-limited conditions.
Zhang H, Ha Z, Wei A, Zhao C, Meng G, Li X, Wu F, Liu J, Wu H, Ma Q, Xie X. · 2026-06-18
open access unreviewed -
9
Elevated miR-103b in exosomes derived from brain-metastatic triple-negative breast cancer cells remodels the brain pre-metastatic niche (PMN).
Zhou L, Ke J, Zhang S, Xiao S, Zhang H, Liu S, Liu L, Liu M, Lu Z, Zheng S. · 2026-09-25
open access unreviewed -
10
MAFF is a transcription factor that regulates contraction-induced skeletal muscle transcription.
Fukushima T, Fujioka T, Masubuchi S, Sakakibara I. · 2026-09-08
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.