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unreviewed

ATP-citrate lyase (ACLY)

1 reactions · 1 pathways

Cofactors used

ATP CoA-SH · B5 (Pantothenic acid) Pi

What it does, reaction by reaction

1 reactions

Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol

step 2 Irreversible/directional

Citrate (cytosol) + ATP + CoA-SH → acetyl-CoA + oxaloacetate + ADP + Pi

Converts Citrate (cytosol) ATP CoA-SH into Acetyl-CoA Oxaloacetate ADP Pi

› Notes

ATP-citrate lyase cleaves exported citrate and consumes ATP. This reaction supplies cytosolic acetyl-CoA, which cannot cross the inner mitochondrial membrane directly.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Fatty Acid Synthesis (De Novo Lipogenesis)

Listed there as: ATP-citrate lyase

Accelerated by

Citrate availability; insulin-induced expression

Inhibited by

Energy scarcity indirectly limits citrate export

Hormonal control

Insulin increases expression/activity; fasting counterregulatory hormones suppress lipogenic gene expression

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.

    Xiao W, Tan D, Zeng W, Nie X, Wang M. · 2026-01-28

    open access unreviewed
  2. 2
    Chebulinic acid suppresses NF-κB/TSLP signaling axis via ACLY-mediated lipid metabolism reprogramming to ameliorate atopic dermatitis.

    Wang M, Bai Y, Guo Y, Shen X, Yang J, Miao H, Zhang X, Wang P, Kang A, Dang E. · 2026-07-16

    unreviewed
  3. 3
    Acetyl-CoA synthetase 2 maintains cytosolic acetyl-CoA homeostasis to preserve mitochondrial integrity and attenuate cardiac dysfunction under chronic β-adrenergic stress.

    Sekine T, Miura S, Misaka T, Okochi S, Ogawara R, Ichimura S, Yokokawa T, Oikawa M, Waguri S, Ishida T, Takei… · 2026-08-17

    open access unreviewed
  4. 4
    Natural microbiota confer life-long protection against obesity via an early-life, immune-mediated effect on brown adipocytes.

    Azar S, Gavrilova O, Baker G, Oh JH, Fukutomi K, Seishima J, Ma J, Kwak M, Badger JH, Trinchieri G, Hild B, A… · 2026-08-23

    open access unreviewed
  5. 5
    Rotavirus-NSP5 interacts with and hijacks host ATP citrate lyase to viroplasms, enhancing lipid biosynthesis for facilitating rotavirus infection.

    Sharma R, Banerjee S, Chaudhuri RD, Dey KK, Gope A, Miyoshi SI, Imamura D, Chawla-Sarkar M. · 2026-08-16

    cited 1× open access unreviewed
  6. 6
    Decoding osteosarcoma pathogenesis: the pivotal influence of m<sup>6</sup>A modification.

    Huang C, Han Z, Su J, Zhang M, Lin Y, He H, Tang Y, Guo P, Wang Y, Chen H. · 2026-07-21

    open access unreviewed
  7. 7
    Hijacking and subversion of macrophage antiviral functions by viruses.

    Xu Z, Shi F, Han J, Zhou L, Yang H. · 2026-06-29

    open access unreviewed
  8. 8
    New insights into the ACLY-mediated metabolic and epigenetic interplay in macrophages.

    Yuan L, Wang T, Song Y, Guo P, Zhu Y, Cao Y, Song B, Yu Z. · 2026-06-25

    open access unreviewed
  9. 9
    MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming.

    Kisielewska M, Suwała S, Drąg-Zalesińska M, Rembiałkowska N. · 2026-06-15

    open access unreviewed
  10. 10
    Emerging roles of ATP citrate lyase in kidney diseases: from pathogenic driver to therapeutic target.

    Wei M, Tao M, Tan H, Jin Z, Yang Y, Xiao Z, Li G, Chen Y. · 2026-04-09

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.