unreviewed

ATP-citrate lyase (ACLY)

1 reactions · 1 pathways

Cofactors used

ATP CoA-SH · B5 (Pantothenic acid) Pi

What it does, reaction by reaction

1 reactions

Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol

step 2 Irreversible/directional

Citrate (cytosol) + ATP + CoA-SH → acetyl-CoA + oxaloacetate + ADP + Pi

Converts Citrate (cytosol) ATP CoA-SH into Acetyl-CoA Oxaloacetate ADP Pi

› Notes

ATP-citrate lyase cleaves exported citrate and consumes ATP. This reaction supplies cytosolic acetyl-CoA, which cannot cross the inner mitochondrial membrane directly.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Fatty Acid Synthesis (De Novo Lipogenesis)

Listed there as: ATP-citrate lyase

Accelerated by

Citrate availability; insulin-induced expression

Inhibited by

Energy scarcity indirectly limits citrate export

Hormonal control

Insulin increases expression/activity; fasting counterregulatory hormones suppress lipogenic gene expression

Recent literature

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Europe PMC · fetched just now · sorted by publication date

1
Chebulinic acid suppresses NF-κB/TSLP signaling axis via ACLY-mediated lipid metabolism reprogramming to ameliorate atopic dermatitis.
Wang M, Bai Y, Guo Y, Shen X, Yang J, Miao H, Zhang X, Wang P, Kang A, Dang E. · 2026-07-16

unreviewed
2
New insights into the ACLY-mediated metabolic and epigenetic interplay in macrophages.
Yuan L, Wang T, Song Y, Guo P, Zhu Y, Cao Y, Song B, Yu Z. · 2026-06-25

unreviewed
3
MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming.
Kisielewska M, Suwała S, Drąg-Zalesińska M, Rembiałkowska N. · 2026-06-15

open access unreviewed
4
Emerging roles of ATP citrate lyase in kidney diseases: from pathogenic driver to therapeutic target.
Wei M, Tao M, Tan H, Jin Z, Yang Y, Xiao Z, Li G, Chen Y. · 2026-04-09

open access unreviewed
5
Porphyromonas gingivalis secreted factors drive epithelial-mesenchymal transition (EMT) through gingipains and an H2S-mediated bacterial defense system.
Kazelnik M, Masri R, Caspi M, Wittenstein A, Tsarfaty I, Borenstein E, Caller T, Shatalin K, Nudler E, Rosin-… · 2026-03-24

open access unreviewed
6
Super-enhancer-associated miR-1260b coordinates adipogenesis and metabolic programming in human adipose stem cells.
Li S, Ji S, Yu Z, Liu H, Wu J. · 2026-03-13

open access unreviewed
7
Metabolic control of macrophages in coronavirus disease 2019.
An L, Xu H, Fan Q, Lu M, Sun D. · 2025-12-26

open access unreviewed
8
Aerobic exercise reduces lipid accumulation via ACLY-mediated metabolic remodeling to alleviate cardiac remodeling.
Zhang G, Yang Z, Zhang M, Zhang D, Gao J, Wang L, Zheng X, Wang K, Chao R, Lv X, Zhao L, Du Y. · 2026-07-13

unreviewed
9
Effects of dissolved oxygen and carbon source forms on carbon source capture efficiency in activated sludge system: Carbon allocation pathways and surface characteristic differences.
Zhang P, Wang JY, Liu SY, Guo JS, Fang F, Chen YP, Yan P. · 2026-06-01

unreviewed
10
Disrupting adenosine triphosphate metabolism as a therapeutic strategy against lymphatic cancer progression: a review.
Qutub M, Premchandani T, Faizan M, Tatode A, Khan R, Taksande J, Umekar M, Singh M, Sharma P. · 2026-05-15

unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.