unreviewed

ATP-citrate lyase (ACLY)

1 reactions · 1 pathways

Cofactors used

ATP CoA-SH · B5 (Pantothenic acid) Pi

What it does, reaction by reaction

1 reactions

Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol

step 2 Irreversible/directional

Citrate (cytosol) + ATP + CoA-SH → acetyl-CoA + oxaloacetate + ADP + Pi

Converts Citrate (cytosol) ATP CoA-SH into Acetyl-CoA Oxaloacetate ADP Pi

› Notes

ATP-citrate lyase cleaves exported citrate and consumes ATP. This reaction supplies cytosolic acetyl-CoA, which cannot cross the inner mitochondrial membrane directly.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Fatty Acid Synthesis (De Novo Lipogenesis)

Listed there as: ATP-citrate lyase

Accelerated by

Citrate availability; insulin-induced expression

Inhibited by

Energy scarcity indirectly limits citrate export

Hormonal control

Insulin increases expression/activity; fasting counterregulatory hormones suppress lipogenic gene expression

Recent literature

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