Phosphatidylethanolamine N-methyltransferase (PEMT)
Cofactors used
What it does, reaction by reaction
Phospholipid Synthesis (Kennedy / CDP pathways) Lipid Metabolism · ER / Golgi
Phosphatidylethanolamine + 3 SAM -> phosphatidylcholine + 3 SAH
Converts Phosphatidylethanolamine S-adenosylmethionine (SAM) into Phosphatidylcholine S-adenosylhomocysteine
› Notes
Hepatic salvage route to PC; a major consumer of SAM and a link to the methionine cycle.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
<i>Porphyromonas gingivalis</i> secreted factors drive epithelial-mesenchymal transition (EMT) through gingipains and an H<sub><b>2</b></sub>S-mediated bacterial defense system.
Kazelnik M, Masri R, Caspi M, Wittenstein A, Tsarfaty I, Borenstein E, Caller T, Shatalin K, Nudler E, Rosin-… · 2026-03-24
open access unreviewed -
2
Interactions between nutrition and the epigenome: how can it be harnessed for public health?
Anastasopoulou M, Dereki I, Sgourou A, Lagoumintzis G. · 2026-03-12
cited 2× open access unreviewed -
3
Alcohol consumption in metabolic dysfunction-associated steatotic liver disease (MASLD): understanding the gut-liver crosstalk for clinical translation.
Benedé-Ubieto R, Estévez-Vázquez O, Acar R, Leal-Lassalle H, Gutierrez AH, Redondo-Urzainqui A, Iborra S, Odi… · 2026-02-21
cited 4× open access unreviewed -
4
Genetics of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) in the Indian Ethnicity: An Update.
Vishnubhotla R, Bale G, Kulkarni AV, Duvvur NR, Padaki NR. · 2026-07-17
unreviewed -
5
Development and Validation of a Crotonylation-Related Prognostic Risk Model for Cholangiocarcinoma Based on Integrative Transcriptome Analysis.
He X, Lv M, Chen J, Zhu Q, Zhao J, Chen W. · 2026-07-04
unreviewed -
6
Renal Tubular Epithelial Cells Senescence Induced by 1‐Aminopyrene Activates Fibroblast via BRD4 Driven Senescence‐Associated Secretory Phenotype Signaling
Katarkar A, Bagde A, Maurya D, Chahare B, Mane N, Sivanesan S, Krishnamurthi K. · 2026-10-01
open access unreviewed -
7
Analysis of lipid-protein interactive oxidation and underlying pathways in aquatic products via multi-omics and machine learning: a case study of air-dried hairtail.
Luo Y, Lin HM, Liu S, Benjakul S, Zhang B. · 2026-08-28
open access unreviewed -
8
Transcriptome and Functional Analysis Uncover the Role of ADCY5 in Bovine Adipogenesis.
Wei X, Shan X, Yang L, Zhao X, Ma Y, Zhang P, Xu Y, Hao R. · 2026-10-01
unreviewed -
9
ITGA6⁺ epithelial cell-associated bone invasion in head and neck squamous cell carcinoma: Single-cell sequencing reveals epithelial-mesenchymal transition as a major factor.
Guo B, Sun L, Chen J, Wen X, Liu Z, Zhang X, Zhao Z, Wang X, Yang J. · 2026-08-03
open access unreviewed -
10
Nutrigenomic regulation of one-carbon metabolism and the circadian clock in health and disease.
Fustin JM. · 2026-10-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.