unreviewed

Phosphatidylethanolamine N-methyltransferase (PEMT)

1 reactions · 1 pathways

Cofactors used

SAM

What it does, reaction by reaction

1 reactions

Phospholipid Synthesis (Kennedy / CDP pathways) Lipid Metabolism · ER / Golgi

step 6 Irreversible/directional

Phosphatidylethanolamine + 3 SAM -> phosphatidylcholine + 3 SAH

Converts Phosphatidylethanolamine S-adenosylmethionine (SAM) into Phosphatidylcholine S-adenosylhomocysteine

› Notes

Hepatic salvage route to PC; a major consumer of SAM and a link to the methionine cycle.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

1
Porphyromonas gingivalis secreted factors drive epithelial-mesenchymal transition (EMT) through gingipains and an H2S-mediated bacterial defense system.
Kazelnik M, Masri R, Caspi M, Wittenstein A, Tsarfaty I, Borenstein E, Caller T, Shatalin K, Nudler E, Rosin-… · 2026-03-24

open access unreviewed
2
Interactions between nutrition and the epigenome: how can it be harnessed for public health?
Anastasopoulou M, Dereki I, Sgourou A, Lagoumintzis G. · 2026-03-12

open access unreviewed
3
Alcohol consumption in metabolic dysfunction-associated steatotic liver disease (MASLD): understanding the gut-liver crosstalk for clinical translation.
Benedé-Ubieto R, Estévez-Vázquez O, Acar R, Leal-Lassalle H, Gutierrez AH, Redondo-Urzainqui A, Iborra S, Odi… · 2026-02-21

cited 2× open access unreviewed
4
Centrosome-related gene SPHK1 drives bladder cancer progression and therapeutic vulnerability.
Dong C, Fang Z, Han Y, Yin Y, Cao Y, Lu Q. · 2026-07-22

unreviewed
5
Are sustainable plant-based diets suitable for all? A nutrigenetic perspective.
Terzioğlu E, Kalkan I. · 2026-08-13

unreviewed
6
Precision omic portrait deciphers the epigenetic variable during cellular identity reshaping of metastatic head and neck squamous cell carcinoma.
Feng Q, Shan X, Xia Y, Liao L, Kang Y, Li Z, Dai Z, Chai Y, Zhang X, Wang L, Xie S, Cai Z. · 2026-06-30

unreviewed
7
Development and Validation of a Crotonylation-Related Prognostic Risk Model for Cholangiocarcinoma Based on Integrative Transcriptome Analysis.
He X, Lv M, Chen J, Zhu Q, Zhao J, Chen W. · 2026-07-04

unreviewed
8
Pemt Inhibition-Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High-Fat Diet-Derived Liver Injury.
Bu X, Cao X, Yao X, Li B, Lai W, Zhao Z, Hao T, Chen Z, Du J, Li Y, Mai K, Ai Q. · 2026-07-02

unreviewed
9
Molecular changes during AT/RT progression associated with epithelial-mesenchymal transition and extracellular matrix changes.
Altendorf L, Althammer A, Roy R, Hack K, de Faria FW, Koch A, Thaden V, Schoof M, Schuhmann MU, Hauser P, Joh… · 2026-07-01

unreviewed
10
BCAS-3 is required for the progression of autophagosome formation to degrade paternal mitochondria in Caenorhabditis elegans.
Norizuki T, Sasaki T, Suehiro Y, Mitani S, Kojima W, Yamano K, Matsuda N, Sato M. · 2026-06-11

open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.