Phenylethanolamine N-methyltransferase (PNMT)
Cofactors used
What it does, reaction by reaction
Catecholamine Synthesis Amino Acid & Nitrogen Metabolism · Cytosol + secretory vesicle
Norepinephrine + SAM -> epinephrine + SAH
Converts Norepinephrine S-adenosylmethionine (SAM) into Epinephrine S-adenosylhomocysteine
› Notes
Confined largely to adrenal medulla, where cortisol from the cortex induces PNMT.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
-
1
Ion chromatography-ultra-high-resolution mass spectrometry reveals EZH2-driven reprogramming of nucleic acid and protein methylation.
Kaddah MMY, Fan TW, Islam JMM, Lin P, Cassel TA, Cunningham R, Brown T, Higashi RM, Lane AN. · 2026-05-13
unreviewed -
2
Metabolic control of renal cell fate in kidney disease: nutrient rewiring, senescence and fibrosis.
Hu H, Ji R, Hu J. · 2026-07-27
unreviewed -
3
Effects of Low Methionine Intake on Gastric Ulcer in Patients and Mice: Role of the NNMT Pathway.
Meng S, Chen F, Chen J, Lin Y, Chen R, Yan Q, Qin Q, Yu R, Jiang P, Wu G. · 2026-07-01
unreviewed -
4
Nicotinamide N-Methyltransferase Epigenetically Activates Fibronectin 1 Through H3K9me3 Remodeling in Clear Cell Renal Cell Carcinoma.
Wang L, Wang Y, Han Q, Zhou X, Wu C, Zhang H, Liang Z, Lai M. · 2026-07-05
unreviewed -
5
Multi-Omics profiling identify NNMT in tumor endothelium as a key regulator of CD8⁺ T cell exhaustion via the TGF signaling pathway.
Wang L, He H, Su K, Gao Y, Luo Y, Tan H, Liu Z, Xu K, Li Y, Li X. · 2026-05-17
cited 1× open access unreviewed -
6
Cancer-Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT-ANGPTL4 Axis.
Lu S, Ke S, Yu H, Meng Z, Bai M, Xu Y, Zhu H, Yang J, Qian B, Yin B, Wang C, Feng Z, Li Z, Zhou Y, Li Z, Li X… · 2026-04-14
unreviewed - 7
-
8
Rare Truncating HAND2 Variants Predispose to Atrial Fibrillation
Zhang H, Hu X, Li N, Zhang D, Qiu X, Yang C, Xu Y, Yang Y, Wang J. · 2026-06-01
open access unreviewed -
9
Homovanillic acid and vanillylmandelic acid as neuroblastoma biomarkers in children.
Kavalakatt S, Ivica J. · 2026-06-01
open access unreviewed -
10
The biological roles and therapeutic potential of nicotinamide N-methyltransferase in ovarian cancer.
Hadi S, Darabi AHK, Pourseif MM, Alirezae P, Fattahpour SF, Nejabati HR, Khaniani MS. · 2026-06-04
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.