Phenylethanolamine N-methyltransferase (PNMT)
Cofactors used
What it does, reaction by reaction
Catecholamine Synthesis Amino Acid & Nitrogen Metabolism · Cytosol + secretory vesicle
Norepinephrine + SAM -> epinephrine + SAH
Converts Norepinephrine S-adenosylmethionine (SAM) into Epinephrine S-adenosylhomocysteine
› Notes
Confined largely to adrenal medulla, where cortisol from the cortex induces PNMT.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Reconstituting a two-step pathway for <i>N</i>,<i>N</i>-dimethyltryptamine (DMT) biosynthesis in bacteria.
Junges LH, Pontes FLD, Mota FJT, Passaglia Bruschi G, Bonaldi MPF, de Souza EM, Müller-Santos M. · 2026-07-21
open access unreviewed -
2
Environmental cues signal through circadian control of sarcomeric gene expression during cardiomyocyte hypertrophy.
Arrieta A, Jennings A, Dasgupta P, Gehred ND, Gromova T, Sandoval E, Song K, Eghbali M, Fischer MA, Vondriska… · 2026-07-22
cited 1× open access unreviewed - 3
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4
Thyroxine binding globulin deficiency due to a novel <i>HNF1B</i> gene variant in a young girl with high thyroxine requirement.
Manasa CVS, Bora A, A V Alekya L, Mashetty S, Guddeti A, Hari Kumar KVS. · 2026-09-23
open access unreviewed -
5
Metabolic-epigenetic vulnerability in cardiometabolic HFpEF: One-carbon metabolism, DNMT maintenance, and methylation instability.
Luo W, Zuo W, Xu Y, Yang M, Ji Z, Ma G. · 2026-08-20
unreviewed -
6
Metabolic control of renal cell fate in kidney disease: nutrient rewiring, senescence and fibrosis.
Hu H, Ji R, Hu J. · 2026-07-27
unreviewed -
7
Nutrigenomic regulation of one-carbon metabolism and the circadian clock in health and disease.
Fustin JM. · 2026-10-01
open access unreviewed -
8
Catecholamine metabolism revisited: from neurochemistry to integrative physiology and pathophysiology.
Goldstein DS, Eisenhofer G. · 2026-06-26
unreviewed -
9
The biological roles and therapeutic potential of nicotinamide N-methyltransferase in ovarian cancer.
Hadi S, Darabi AHK, Pourseif MM, Alirezae P, Fattahpour SF, Nejabati HR, Khaniani MS. · 2026-06-04
unreviewed -
10
The Lactate-Lactylation Axis as a Metabolic-Epigenetic Framework for Therapeutic Adaptation in Esophageal Squamous Cell Carcinoma.
Yu J, Cui Y, Li S, Guo X, Li N, Gu Y, Jin Y, Chen Y, Li X, Yan Y, Wu Z, Zhu C, Feng L. · 2026-09-16
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.