unreviewed

Orotate phosphoribosyltransferase (UMP synthase domain 1)

1 reactions · 1 pathways

Cofactors used

Clinical / pharmacological. Hereditary orotic aciduria: megaloblastic anaemia unresponsive to B12/folate; treat with uridine

What it does, reaction by reaction

1 reactions

Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)

step 5 Irreversible

Orotate → orotidine 5′-monophosphate (OMP)

Converts Orotate into Orotidine 5'-monophosphate (OMP)

› Notes

Orotate phosphoribosyltransferase (OPRT), the first activity of bifunctional UMP synthase, catalyzes orotate + PRPP → OMP + PPi. Mg2+ is required, and PPi hydrolysis makes the step effectively irreversible.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

1
Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.
Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01

open access unreviewed
2
GPX1 drives cuproptosis-ferroptosis resistance in cold tumors.
Yang S, Zhang C, Mei Z, Ye Q, Guo G, Zhu G, Zheng X, Cui Y, Gu W, Zhou Y, Liu G, Wang G, Yang Z. · 2026-07-02

unreviewed
3
Effects of Topical Administration of Bupivacaine HCl to the Ovarian Pedicle on Postoperative Pain, Antioxidant Enzyme Activity and Inflammatory Cytokines in Dogs Undergoing Laparoscopic Ovariectomy.
Çiplak AY, Polat B. · 2026-09-01

unreviewed
4
A retrospective cohort study of surgery for adrenocortical carcinoma in a tertiary endocrine surgery unit.
Kamalakkannan N, Tahir F, O'Toole S, Al-Mukhtar A, Newell-Price J, Balasubramanian SP. · 2026-08-06

unreviewed
5
Ion chromatography-ultra-high-resolution mass spectrometry reveals EZH2-driven reprogramming of nucleic acid and protein methylation.
Kaddah MMY, Fan TW, Islam JMM, Lin P, Cassel TA, Cunningham R, Brown T, Higashi RM, Lane AN. · 2026-05-13

unreviewed
6
Malignancy Risk Within Hyperfunctioning Thyroid Nodules: Clinicopathologic Features and Diagnostic Implications.
Huang PJ, Chi SY, Huang SC, Chang YH, Chou CK. · 2026-07-18

unreviewed
7
A UiO-66@MR paper-based colorimetric sensor for sensitive detection of food spoilage volatile organic compounds and visual freshness monitoring.
Kong Y, Feng X, Sun W, Bi Y, Song C, Liu S. · 2026-07-01

unreviewed
8
De novo pyrimidine synthesis controls germinal center B cell and plasma cell fates and systemic autoimmunity.
Weber JL, Bui T, Nuon K, Fike AJ, Crocker SM, Bricker KN, Maharjan A, Zhang W, Goldman AR, Chodisetti SB, Rah… · 2026-06-22

unreviewed
9
DHODH-Mediated Suppression of Ferroptosis Supports Radioresistance and Represents a Therapeutic Vulnerability in Lung Cancer.
Mao C, Wu S, Rajacharya GH, Wang M, Lu Z, Huo D, Yan Y, Chen X, Lei G, Xu Z, Li Q, Sun M, Zhao X, Zhuang L, J… · 2026-07-01

unreviewed
10
Legal Infoveillance of Unlicensed Medical Practices in South Korea Through Criminal Court Decisions Using Machine Learning: Retrospective Observational Study.
Kim MJ, Choi M. · 2026-06-15

unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.