What it does, reaction by reaction
Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)
Orotate → orotidine 5′-monophosphate (OMP)
Converts Orotate into Orotidine 5'-monophosphate (OMP)
› Notes
Orotate phosphoribosyltransferase (OPRT), the first activity of bifunctional UMP synthase, catalyzes orotate + PRPP → OMP + PPi. Mg2+ is required, and PPi hydrolysis makes the step effectively irreversible.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.
Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01
open access unreviewed -
2
Metabolic regulation of uridine in diabetic kidney disease and its pharmacological modulation by schisandrin B.
Yuan Y, Yu L, Gu Y, Liu X, Bi C, Li Y, Wang Y, Yang S, Yang L, Ning L, Yang C, Huang W, Wei J, Li Y. · 2026-08-27
unreviewed -
3
A comprehensive review on apoptotic miRNAs and antagomiRs in breast cancer: Enhancing radio sensitization.
Najafi-Amiri M, Pourhabib-Mamaghani M, Aghaee-Bakhtiari SH, Bahreyni-Toossi MT, Azimian H. · 2026-04-22
open access unreviewed -
4
Chromatin interaction landscape of epimorphic regeneration in teleost fish
Jia X, Zhang X, Lin W, Ren T, Liu S, Lou Y, Wang W. · 2026-10-09
open access unreviewed -
5
GPX1 drives cuproptosis-ferroptosis resistance in cold tumors.
Yang S, Zhang C, Mei Z, Ye Q, Guo G, Zhu G, Zheng X, Cui Y, Gu W, Zhou Y, Liu G, Wang G, Yang Z. · 2026-07-02
unreviewed -
6
Mesenchymal stem cell-derived extracellular vesicle treatment of induced pluripotent stem cell-derived motor neurons with different amyotrophic lateral sclerosis genetic backgrounds.
Varderidou-Minasian S, Jakobs CE, Pasteuning-Vuhman S, Gal L, Timmers A, Altelaar M, Lorenowicz MJ, Pasterkam… · 2026-02-05
open access unreviewed -
7
Gut microbiota-mediated modulation of circadian rhythms: Physiological and molecular impacts of dietary composition and feeding time.
Koh YC, Chang CC, Pan MH. · 2026-09-01
open access unreviewed -
8
Japanese encephalitis virus reprograms host pyrimidine metabolism to facilitate viral replication.
Gu J, Fan C, Xiang S, Si Y, Zhu B, Cao S, Ye J. · 2026-07-31
open access unreviewed -
9
The GPX3-VCAM1 Axis Gates Pro-Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy.
Qi Y, Zhao Q, Lve Y, Yuan Y, Zhou T, Yuan Y, Wu D, Tang Y, Liu Y, Li Z, Jiang C, Ding Q. · 2026-09-09
open access unreviewed -
10
Evaluation of peak alignment performance of commercial and open-source tools for GC×GC-MS based non-targeted screening.
Rebryk A, van Herwerden D, Samanipour S, Haglund P. · 2026-09-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.