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unreviewed

AMP deaminase (adenylate deaminase)

1 reactions · 1 pathways

Cofactors used

H2O

What it does, reaction by reaction

1 reactions

Purine Degradation (to Uric Acid) Nucleotide Metabolism · Cytosol

step 2 Irreversible/directional

AMP → IMP

Converts AMP into IMP

› Notes

AMP deaminase (adenylate deaminase) catalyzes AMP + H2O → IMP + NH3. This route is prominent in exercising skeletal muscle and in the purine nucleotide cycle; it is not the universal route of AMP degradation.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Purine Degradation (to Uric Acid)

Listed there as: AMP deaminase

Accelerated by

High AMP, especially during ATP depletion in muscle

Inhibited by

ATP, GTP, and phosphate-dependent energy sufficiency signals (isoform dependent)

Hormonal control

No principal direct endocrine control; enzyme activity rises functionally during intense exercise/energy stress.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Identification of a mechanical signaling pathway activating type 1 fimbriae via a ZraSR two-component system in neonatal meningitis-associated <i>Escherichia coli</i>.

    Li X, Wang J, Li Z, Guo X, Wang Y, Chen X, Zheng Y, Zhang Q, Liu R, Sun X, Liu B, Sun H. · 2026-09-11

    open access unreviewed
  2. 2
    PD-1 blockade promotes mucosal CD4+ T cell IL-10 production through altering microbiota to reduce intestinal ischemia reperfusion injury.

    Wen SH, Zhang YN, Shen JT, Guo Y, Chang ZN, Zhang HF, Liu ZM, Zhang XY. · 2026-03-06

    open access unreviewed
  3. 3
    Neuroelectrophysiological clinical exploration of reward expectation and sensitivity abnormalities in adolescent melancholic MDD.

    Liu Z, Qi Y, Cheng W, Wen Y, Qiao D, Zhang Y, Huang F, Lu Y, Li G, Li H, Yang C. · 2026-06-12

    unreviewed
  4. 4
    Ectomycorrhizal Cortinariaceae species dominate class II peroxidase gene expression in a boreal forest soil.

    Barbi F, Menzel U, Simone D, Niskanen T, Lindahl BD. · 2026-08-13

    cited 1× open access unreviewed
  5. 5
    Zerumbone Combined with Hydrolytic Enzymes: A Promising Strategy to Control Mixed Biofilms of <i>Streptococcus mutans</i> and Fluconazole-Resistant <i>Candida albicans</i>.

    de Oliveira AB, Panariello BHD, Barbugli PA, Ferrisse TM, Pavarina AC. · 2026-08-19

    open access unreviewed
  6. 6
    Integrated Multi-Omic Analyses Reveal Gender-Specific Molecular Mechanisms Regulating Growth and Muscle Development in Zhongshan Partridge Ducks.

    Ouyang T, Chao X, Yin Y, Ji C, Ma X, He Y, Cui T, Zhong H, Wu Z, Luo Q. · 2026-09-14

    open access unreviewed
  7. 7
    Nanopore long-read transcriptome sequencing reveals miR-22-3p-mediated transcriptomic remodeling and alternative splicing in chicken pectoral muscle.

    Yi J, Chen J, Xu J, Cai Y, Zong Y, Run M, Qian B, Xie Q, Luo X, Liu B, Zhang X, Guo J, Ye F, Xiang H, Li H, M… · 2026-09-13

    open access unreviewed
  8. 8
    Alteration in adenosine monophosphate deaminase activity and ferric reducing capacity in diabetic renal failure patients.

    Hammad LS, Abdulmohsin Zainulabdeen J. · 2026-07-01

    open access unreviewed
  9. 9
    A multi-omic atlas of the maternal-fetal dyad reveals metabolic stratification and prenatal signatures potentially relevant to meat quality development.

    Huang P, Li Z, Liu J, Li Y, Li Z, Xi R, Liu M. · 2026-09-11

    unreviewed
  10. 10
    Westernized diet related arachidonic acid metabolism expands DNA error-prone growth factor-dependent colonic quiescent stem cells in adolescent mice.

    Christiansen L, Ragab M, Nickel L, Sünderhauf A, Jegodzinski L, Hicken M, Schlichting H, Weikamp R, Schmelter… · 2026-09-14

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.