unreviewed

AMP deaminase (adenylate deaminase)

1 reactions · 1 pathways

Cofactors used

H2O

What it does, reaction by reaction

1 reactions

Purine Degradation (to Uric Acid) Nucleotide Metabolism · Cytosol

step 2 Irreversible/directional

AMP → IMP

Converts AMP into IMP

› Notes

AMP deaminase (adenylate deaminase) catalyzes AMP + H2O → IMP + NH3. This route is prominent in exercising skeletal muscle and in the purine nucleotide cycle; it is not the universal route of AMP degradation.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Purine Degradation (to Uric Acid)

Listed there as: AMP deaminase

Accelerated by

High AMP, especially during ATP depletion in muscle

Inhibited by

ATP, GTP, and phosphate-dependent energy sufficiency signals (isoform dependent)

Hormonal control

No principal direct endocrine control; enzyme activity rises functionally during intense exercise/energy stress.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

1
PD-1 blockade promotes mucosal CD4+ T cell IL-10 production through altering microbiota to reduce intestinal ischemia reperfusion injury.
Wen SH, Zhang YN, Shen JT, Guo Y, Chang ZN, Zhang HF, Liu ZM, Zhang XY. · 2026-03-06

open access unreviewed
2
Neuroelectrophysiological clinical exploration of reward expectation and sensitivity abnormalities in adolescent melancholic MDD.
Liu Z, Qi Y, Cheng W, Wen Y, Qiao D, Zhang Y, Huang F, Lu Y, Li G, Li H, Yang C. · 2026-06-12

unreviewed
3
Guanidinoacetic acid improves flesh quality associated with collagen synthesis and nucleotide metabolism in gibel carp CAS V (<i>Carassius gibelio</i>, CAS V).
Wang Y, Zhang Y, Wu L, Li C, Chen Q, Han D, Liu H, Zhang Z, Xie S, Jin J. · 2026-04-03

open access unreviewed
4
Proteomic profiling of valproic acid-treated zebrafish embryos highlights dysregulation in energy and purine metabolism, and microtubule dynamics: Implications for autism spectrum disorder.
Sürmen S, Sürmen MG, Beler M, Ünal İ, Cansız D, Emekli-Alturfan E. · 2026-05-06

unreviewed
5
Role of AMPD1 in metabolic regulation: Functions and applications.
Sun J, Xiong L, Yuan L, Gou H, Xiong Y, Song X. · 2026-06-25

unreviewed
6
Atypical Tetracyclines Promote Longevity and Ferroptotic Neuroprotection via Translation Attenuation.
Clay KJ, Sanchez-Alavez M, Newman I, Na N, Espinoza APV, To A, Saad S, Cline HT, Petrascheck M. · 2026-06-01

open access unreviewed
7
Age-Dependent Remodeling of the Sciatic Nerve Proteome in 5xFAD Mice Can Be Attenuated by Exercise or Donepezil Treatment to Maintain Neuromuscular Function.
Brisendine MH, Nieves-Esparcia DQ, Willoughby OS, Brown B, Brown JR, Braxton DS, Henry SN, McCoin CS, Thyfaul… · 2026-06-01

open access unreviewed
8
An appendiceal cancer organoid biobank identifies phenotypic evolution and druggable dependencies of peritoneal carcinomatosis.
Mahmoud A, Sukhwa C, Giarrizzo M, Choi PH, Pintar J, Walch H, Zhao N, Bermeo J, Chung S, Raghavan M, Bapat S,… · 2026-05-26

cited 1× unreviewed
9
Investigation of the effects and underlying mechanisms of adenylate kinase 1 on inosine monophosphate deposition in Beijing-You chickens.
Hou J, Zhang Y, Zhu L, Qi X, Wang X, Lin Z, Xiao L, Long C, Dou J, Xu Y, Sheng X. · 2026-03-23

open access unreviewed
10
Integrated transcriptomic and metabolomic analysis identifies C5NT1AL as a candidate gene influencing inosine monophosphate levels in chicken breast muscle.
Yang H, Liu L, Wang Y, Wang Y, Zhuang J, Cui H, Zhao G, Wen J. · 2026-03-14

open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.