unreviewed

AMP deaminase (adenylate deaminase)

1 reactions · 1 pathways

Cofactors used

H2O

What it does, reaction by reaction

1 reactions

Purine Degradation (to Uric Acid) Nucleotide Metabolism · Cytosol

step 2 Irreversible/directional

AMP → IMP

Converts AMP into IMP

› Notes

AMP deaminase (adenylate deaminase) catalyzes AMP + H2O → IMP + NH3. This route is prominent in exercising skeletal muscle and in the purine nucleotide cycle; it is not the universal route of AMP degradation.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Purine Degradation (to Uric Acid)

Listed there as: AMP deaminase

Accelerated by

High AMP, especially during ATP depletion in muscle

Inhibited by

ATP, GTP, and phosphate-dependent energy sufficiency signals (isoform dependent)

Hormonal control

No principal direct endocrine control; enzyme activity rises functionally during intense exercise/energy stress.

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