What it does, reaction by reaction
1 reactions
Deoxyribonucleotide Formation (Ribonucleotide Reductase pathway and thymidylate synthesis) Nucleotide Metabolism · Cytosol
step 4
Irreversible/directional
dUDP → dUTP → dUMP
› Notes
NDPK phosphorylates dUDP to dUTP, and dUTPase hydrolyzes dUTP + H2O → dUMP + PPi. dUTPase is functionally crucial: it creates dUMP while minimizing dUTP incorporation into DNA, which would otherwise initiate repeated uracil-excision repair.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Pharmacogenetic variation influences sensory neuropathy occurrence in Southern Africans treated with stavudine-containing antiretroviral therapy.
Moketla MB, Wadley AL, Kamerman P, de Assis Rosa D. · 2018-10-01
cited 7× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.