ALA dehydratase (ALAD; porphobilinogen synthase)
Cofactors used
Clinical / pharmacological. Inhibited by lead: lead poisoning with basophilic stippling, elevated ALA
What it does, reaction by reaction
Heme Biosynthesis (Porphyrin Pathway) Amino Acid & Nitrogen Metabolism · Mitochondrion + cytosol
2 ALA → porphobilinogen (PBG) + 2 H₂O
Converts delta-Aminolevulinate (ALA) into Porphobilinogen (PBG) H2O
› Notes
Cytosolic ALA dehydratase (porphobilinogen synthase) condenses two ALA molecules and requires catalytic zinc and sulfhydryl integrity. This is an essentially irreversible condensation; lead inhibits the enzyme by disrupting zinc/sulfhydryl-dependent function.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Heme Biosynthesis (Porphyrin Pathway)
Listed there as: ALA dehydratase
Adequate zinc and sulfhydryl integrity
Lead; severe zinc deficiency
No major direct hormonal control
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Heavy metal contamination in cosmetic hair dyes, dermal health risk assessment, and in vivo toxicological implications among exposed women in Khartoum, Sudan.
Mohamed FAH, Al-Hadiya BMH, Alghadi RY, Abadi RSM, Bakheit AH. · 2026-08-26
open access unreviewed -
2
Glycine improves boar sperm linear motility by promoting heme biosynthesis to regulate mitochondrial energy metabolism.
Liu Y, Zhang H, Meng Q, Wu J, Min L, Zeng W, Zhu Z. · 2026-08-29
unreviewed -
3
Discovery of ALA-hydroxypyridinone hybrids: novel strategies for photodynamic therapy against superficial tumours.
Jiang X, Feng M, Niu X, Wang S, Sun Y, Chen W, Bai R. · 2026-07-08
open access unreviewed -
4
Routine care practices for stable lung allograft recipients beyond the initial post-transplant year: An international survey study.
Toporek AH, Gannon WD, Croglio MP, Motta-Calderon D, Dragnich AG, Chapin KC, Hoetzenecker K, Erasmus DB, Trin… · 2026-08-12
open access unreviewed -
5
Phenotyping immune sensitization reveals pattern-based association with post-lung transplant complications.
Siringan MJ, Kaiho T, Reichenbach R, Arunachalam A, Miyashita Y, Yagi Y, Bharat A, Kurihara C. · 2026-07-17
open access unreviewed - 6
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7
Supramolecular Behaviour of Heterochiral Dipeptides With Ile.
Scarel E, Alletto P, Adorinni S, Fazio F, Pierri G, Tedesco C, Marchesan S. · 2026-10-01
open access unreviewed -
8
Dynamic alterations in labile heme levels and heme biosynthesis during inflammatory activation of macrophages.
Jin Y, Pradhan P, Liang H, Nakagiri T, Mueller S, Foresti R, Motterlini R, Hirayama T, Immenschuh S. · 2026-07-16
open access unreviewed -
9
Patient selection refines total hip arthroplasty free survival after hip arthroscopy: an eighteen year, one thousand and fifty one hip cohort study.
Seijas R, Vázquez M, Laiz P, Escutia L, Barastegui D, Ayestarán I, García-Bordes L, Álvarez-Díaz P, Cugat R. · 2026-07-10
unreviewed -
10
Platinum accumulation in chemotherapy: toxicity mechanisms, challenges, and mitigation strategies.
Lai Y, Qiu G, Zheng Z, Huang X, Guo P, Zhang Y, Fang L. · 2026-04-29
cited 1× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.