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unreviewed

ALA dehydratase (ALAD; porphobilinogen synthase)

1 reactions · 1 pathways

Cofactors used

H2O

Clinical / pharmacological. Inhibited by lead: lead poisoning with basophilic stippling, elevated ALA

What it does, reaction by reaction

1 reactions

Heme Biosynthesis (Porphyrin Pathway) Amino Acid & Nitrogen Metabolism · Mitochondrion + cytosol

step 2 Irreversible

2 ALA → porphobilinogen (PBG) + 2 H₂O

Converts delta-Aminolevulinate (ALA) into Porphobilinogen (PBG) H2O

› Notes

Cytosolic ALA dehydratase (porphobilinogen synthase) condenses two ALA molecules and requires catalytic zinc and sulfhydryl integrity. This is an essentially irreversible condensation; lead inhibits the enzyme by disrupting zinc/sulfhydryl-dependent function.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Heme Biosynthesis (Porphyrin Pathway)

Listed there as: ALA dehydratase

Accelerated by

Adequate zinc and sulfhydryl integrity

Inhibited by

Lead; severe zinc deficiency

Hormonal control

No major direct hormonal control

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    An aquatic probiotic alleviates lead toxicity in grass carp (Ctenopharyngodon idella) via improved intestinal barrier function and reduced Pb bioaccumulation.

    Zhou Q, Zheng K, Deng H, Pu Y, Han Z, Chen Y, Su Y. · 2026-07-10

    unreviewed
  2. 2
    From Environmental Lead Exposure to Colorectal Cancer: Integrated Transcriptomic and Genetic Analyses Identify HMOX1 as a Prioritized Candidate.

    Wang L, Qin Y, Wang W, Fan W. · 2026-08-06

    unreviewed
  3. 3
    Early detection of chronic lung allograft dysfunction with spectral and intrabreath oscillometry.

    Fu A, Vasileva A, Hanafi N, Belousova N, Wu JKY, Huszti E, Hantos Z, Chow CW. · 2026-05-04

    open access unreviewed
  4. 4
    Assessment of the duration of lymphocyte depletion after anti-thymocyte globulin for rejection in lung transplant recipients.

    Wert TJ, Rega SA, Morrison M, Hamel S, Feurer ID, Shaver CM. · 2026-04-15

    open access unreviewed
  5. 5
    Proprioceptive role of the abductor pollicis longus in thumb carpometacarpal osteoarthritis: An anatomical and immunohistochemical study.

    Lamas C, Serra J, Fa-Binefa M, Ramirez-Bermejo E, Orellana R, Garcia-Elias M, Ladd AL. · 2026-04-16

    unreviewed
  6. 6
    AI-Predicted Model-Guided Rebuilding of the Experimental Structure of Mouse δ-Aminolevulinic Acid Dehydratase.

    Nam KH. · 2026-07-23

    unreviewed
  7. 7
    Cytotoxic CD8+ T Cells Persist and Show Transcriptional Priming in Lung Transplantation.

    Potter AS, Hayes D. · 2026-07-28

    unreviewed
  8. 8
    Patient selection refines total hip arthroplasty free survival after hip arthroscopy: an eighteen year, one thousand and fifty one hip cohort study.

    Seijas R, Vázquez M, Laiz P, Escutia L, Barastegui D, Ayestarán I, García-Bordes L, Álvarez-Díaz P, Cugat R. · 2026-07-10

    unreviewed
  9. 9
    [Evidence, controversies, and research priorities regarding Low- and No-Calorie Sweeteners (LNCS) in Latin America - Results of the First Latin American Scientific Forum on LNCS].

    Laviada Molina HA, Soto-Méndez MJ, Almeda-Valdés P, Almirón Roig E, Arisseto-Braggoto AP, Ayoub-Charette S, C… · 2026-07-01

    unreviewed
  10. 10
    Risk factors for conversion to total hip arthroplasty after hip arthroscopy for femoroacetabular impingement: a five-year analysis in a large cohort.

    Seijas R, Vázquez-Gómez M, Laiz P, Ferré-Aniorte A, Escutia L, Cugat R. · 2026-06-05

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.