unreviewed

ALA dehydratase (ALAD; porphobilinogen synthase)

1 reactions · 1 pathways

Cofactors used

H2O

Clinical / pharmacological. Inhibited by lead: lead poisoning with basophilic stippling, elevated ALA

What it does, reaction by reaction

1 reactions

Heme Biosynthesis (Porphyrin Pathway) Amino Acid & Nitrogen Metabolism · Mitochondrion + cytosol

step 2 Irreversible

2 ALA → porphobilinogen (PBG) + 2 H₂O

Converts delta-Aminolevulinate (ALA) into Porphobilinogen (PBG) H2O

› Notes

Cytosolic ALA dehydratase (porphobilinogen synthase) condenses two ALA molecules and requires catalytic zinc and sulfhydryl integrity. This is an essentially irreversible condensation; lead inhibits the enzyme by disrupting zinc/sulfhydryl-dependent function.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Heme Biosynthesis (Porphyrin Pathway)

Listed there as: ALA dehydratase

Accelerated by

Adequate zinc and sulfhydryl integrity

Inhibited by

Lead; severe zinc deficiency

Hormonal control

No major direct hormonal control

Recent literature

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