Monoamine oxidase (MAO-A/MAO-B)
Cofactors used
Clinical / pharmacological. MAOI + tyramine: hypertensive crisis
What it does, reaction by reaction
Phase I - Functionalization Xenobiotic & Drug Metabolism · Smooth ER (microsomes), mitochondria
Amine + O2 + H2O -> aldehyde + NH3 + H2O2
Converts Amine O2 H2O into NH3 H2O2
› Notes
Outer mitochondrial membrane; MAO inhibition plus dietary tyramine causes hypertensive crisis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Ameliorative Effects of a Naphthoquinone Derivative With β-Amyloid Aggregation Inhibitory Activity on Cognitive Impairment and Metabolite Analysis of the Blood and Brains of Mice.
Oh JM, Jeong WK, Son HJ, Kim SY, Oh TW, Ji M, Nam JW, Baek M, Park JH, Shin WH, Kim HJ, Choi B, Paik MJ, Kim … · 2026-08-01
unreviewed -
2
A malignant symbiosis: The neuro-metabolic symphony rewires the tumor microenvironment.
Zhang Z, Jia Y, Liu T, Wang S, Liu L. · 2026-06-08
open access unreviewed -
3
Molecular Mechanisms and Network Pharmacology Revealing Therapeutic Potential of Acetamidosulfonamides against Parkinsonian Model.
Ruankham W, Prachayasittikul V, Pingaew R, Tantimongcolwat T, Worachartcheewan A, Chompon K, Ruchirawat S, Pr… · 2026-05-21
open access unreviewed -
4
Uncovering metabolic reprogramming in ovarian and cervical cancers with multi-omics.
Ge Y, Luo Y, Hao B, Zhou Y, Wu R, Liu H, Tang L, Li Y, Li Y, Gong S, Liu H. · 2026-04-22
open access unreviewed -
5
Self-nanoemulsifying drug delivery system (SNEDDS) enhances the antidiabetic potential of <i>Averrhoa bilimbi</i> L. leaf extract: Integrated LC-MS/MS metabolomics, network pharmacology, and alpha-amylase inhibition.
Aryani R, Sarah S, Yuniarni U, Syabihah H, Fakih TM. · 2026-04-23
open access unreviewed -
6
A Serotoninomic Framework for Reproductive and Integrative Toxicology: Molecular, Neurochemical, and Behavioural Perspectives on Permethrin Exposure.
Jiménez-Trejo F, Carmona-Aparicio L, Coballase-Urrutia E, Jiménez-García KL, Arriaga-Canon C, Herrera LA. · 2026-04-24
open access unreviewed -
7
Mechanism prediction of Wenjing Tongluo Powder for post-laparoscopic shoulder pain: A network pharmacology study.
Wei Z, Yu H, Yu S, Wang Y. · 2026-04-01
open access unreviewed -
8
Synaptic Plasticity Fragility Underlies a Microglial Pruning Continuum in Major Depressive Disorder and Amyotrophic Lateral Sclerosis.
Cheung N. · 2026-04-17
open access unreviewed -
9
Unraveling the Mechanisms of Wuling Powder Against MASLD by Integrated Metabolomics-Gut Microbiota-Serum Pharmacochemistry.
Yang H, Tang YM, Han SC, Wang PQ, Tao YX, Yang HQ, Zhang M, Li M, Yu J, Yang XX. · 2026-03-31
open access unreviewed -
10
Impact of NPAS2 on mPFC dopamine synthesis and nap behavior.
Guo L, Cen H, Huang Y, Li Z, Zeng K, Wu Z, Weng J, Guo X, He D, Liu X, Yang Z, Xu H, Hao T, Wei B, Diao X, Wu… · 2026-03-16
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.