Monoamine oxidase (MAO-A/MAO-B)
Cofactors used
Clinical / pharmacological. MAOI + tyramine: hypertensive crisis
What it does, reaction by reaction
Phase I - Functionalization Xenobiotic & Drug Metabolism · Smooth ER (microsomes), mitochondria
Amine + O2 + H2O -> aldehyde + NH3 + H2O2
Converts Amine O2 H2O into NH3 H2O2
› Notes
Outer mitochondrial membrane; MAO inhibition plus dietary tyramine causes hypertensive crisis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology.
Li M, Huang C, Yu S. · 2026-07-02
open access unreviewed -
2
Explore the Mechanism of Xiaoyaosan for Treatment of Bipolar Disorder Based on Network Pharmacology, Experimental Validation and Molecular Docking.
Chen M, Ding N, Qiu X, Li L, Guo Y, Wang R, Mo X, Zou T, Yu S, Li X, Chen J. · 2026-10-01
open access unreviewed -
3
Selective serotonin reuptake inhibitors and immune checkpoint blockade in solid tumors: A target trial emulation with pan-cancer transcriptomic analyses.
Chen PH, Dai MS, Huang MH, Chen HY, Kao LT, Hsieh TY, Jhou HJ, Lee CH. · 2026-09-29
open access unreviewed -
4
System-level synchronization and subtype-specific modules govern brain-wide serotonin axon innervation.
Adams AMJ, Wu KLK, Li Z, Li P, Pan H, Huang Z, Migliarini S, Dear R, Sun B, Chan ZC, Liang J, Li H, Vértes PE… · 2026-09-22
open access unreviewed -
5
Altered Retinal Dopamine Homeostasis in Murine Models of Retinitis Pigmentosa.
Vainionpää K, Lappalainen E, Nilsson A, Pavela I, Torsti T, Seemab U, Mäkinen E, Shariatgorji R, Andrén PE, J… · 2026-09-01
open access unreviewed -
6
Ephedrae Herba-Associated Adverse Events: A Disproportionality Analysis Integrated with Network Pharmacology.
Park M, Shin HK, Choi Y. · 2026-08-24
open access unreviewed -
7
Network Pharmacology Reveals the Potential Mechanism of Ketamine in Improving Cognitive Impairment in Patients With Depression.
Yang L, Zhang Q, Zhang Y, Yao K, Chen X, Tian H, Zhuo C. · 2026-08-06
open access unreviewed -
8
Risk-Aware Computational Prioritization and Validation Route Design for Medicine-Food Homology Plant Compounds in a Parkinson's Disease Context.
Zou J, Wang S, Yong J, Yan L, Hui H, Sun Y. · 2026-08-10
open access unreviewed -
9
Discovery of a Potent and Selective MAO-B Inhibitor From a Donepezil-Linked Chalcone Library With Promising Antiparkinsonian Activity.
Kirac-Aydin A, Pandey BP, Mohanty S, Mondal R, Biswas A, Pattnaik AK, Mondal S, Basavanakatti VN, Bayrak N, J… · 2026-08-01
open access unreviewed -
10
Ameliorative Effects of a Naphthoquinone Derivative With β-Amyloid Aggregation Inhibitory Activity on Cognitive Impairment and Metabolite Analysis of the Blood and Brains of Mice.
Oh JM, Jeong WK, Son HJ, Kim SY, Oh TW, Ji M, Nam JW, Baek M, Park JH, Shin WH, Kim HJ, Choi B, Paik MJ, Kim … · 2026-08-01
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.