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unreviewed

Monoacylglycerol lipase (MGL; MGLL)

1 reactions · 1 pathways

Cofactors used

H2O

What it does, reaction by reaction

1 reactions

Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER

step 10 Irreversible/directional

MAG + H2O → glycerol + free fatty acid

Converts Monoacylglycerol H2O into Glycerol Fatty acid

› Notes

Monoacylglycerol lipase (MGL; MGLL) completes hydrolysis. Released NEFAs bind serum albumin for transport; glycerol travels mainly to liver for glycerol-3-phosphate production, gluconeogenesis, or glycolysis.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    A Critical Assessment of Fasting to Promote Metabolic Health and Longevity.

    Fazeli PK, Steinhauser ML. · 2025-11-01

    cited 9× open access unreviewed
  2. 2
    cAMP driven UCP1 induction in human adipocytes requires ATGL-catalyzed lipolysis.

    Desai A, Loureiro ZY, DeSouza T, Yang Q, Solivan-Rivera J, Corvera S. · 2024-10-23

    cited 10× open access unreviewed
  3. 3
    Regulation of lipolysis by 14-3-3 proteins on human adipocyte lipid droplets.

    Yang Q, Loureiro ZY, Desai A, DeSouza T, Li K, Wang H, Nicoloro SM, Solivan-Rivera J, Corvera S. · 2023-12-06

    cited 10× open access unreviewed
  4. 4
    Kinesin-1-mediated axonal transport of CB1 receptors is required for cannabinoid-dependent axonal growth and guidance.

    Saez TMM, Fernandez Bessone I, Rodriguez MS, Alloatti M, Otero MG, Cromberg LE, Pozo Devoto VM, Oubiña G, Sos… · 2020-04-20

    cited 30× unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.