unreviewed

Mitochondrial thiolase (acetyl-CoA acetyltransferase, T2/ACAT1)

2 reactions · 2 pathways

Cofactors used

CoA-SH · B5 (Pantothenic acid)

What it does, reaction by reaction

2 reactions

Ketogenesis Lipid Metabolism · Liver mitochondrial matrix

step 1 Reversible

2 acetyl-CoA → acetoacetyl-CoA + CoA-SH

Converts Acetyl-CoA into Acetoacetyl-CoA CoA-SH

› Notes

Mitochondrial thiolase (acetyl-CoA acetyltransferase) condenses two acetyl-CoA molecules. This reaction is reversible and is shared conceptually with the terminal thiolysis step of β-oxidation.

Ketolysis (Ketone Body Utilization) Lipid Metabolism · Mitochondrial matrix

step 3 Irreversible/directional

Acetoacetyl-CoA + CoA-SH → 2 acetyl-CoA

Converts Acetoacetyl-CoA CoA-SH into Acetyl-CoA

› Notes

Mitochondrial thiolase cleaves acetoacetyl-CoA. The two acetyl-CoA molecules then enter the TCA cycle.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

1
Circadian reprogramming of inflammation and metabolism in chronic kidney disease.
Li XQ, Cheng L, Chen TF, Ma YN, Li XH, Fu TY, Xiao J, Zhao ZZ. · 2026-09-06

open access unreviewed
2
Branched-chain amino acids and gut microbiota: coregulation and impact on neurological function via the gut-brain axis.
Li Q, Fan B, Xiao Y, Zhang Z, Zhao S, Liao B, Zeng J, Shan X, Ye H, Wen Y, Zhang L, Guo H, Xiao F, Zhu H. · 2026-07-14

open access unreviewed
3
The Crimean-Congo haemorrhagic fever virus hijacks the liver lipid metabolic pathway for virion production.
Gautam A, Zhong L, Ogire E, Bodoirat S, Riedmiller I, Sander WJ, Boson B, Gandhi A, Burlaud-Gaillard J, Amira… · 2026-03-30

open access unreviewed
4
Gut microbiota metabolic reprogramming drives the development of metabolic diseases in the host.
Wang Y, Huang B, Wei X, Guan Y, Li L, Zheng Y, Sun W. · 2026-03-14

cited 40× open access unreviewed
5
Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidation.
Wang W, Gao Y, Chen Y, Cheng M, Wei L, Sang Y, Zhang L, Dai R, Wang Y. · 2026-03-10

open access unreviewed
6
Research progress on lysine acetylation (Review).
Zhang M, Zhang Y, Yin H, Yan J, Dong Y, Zhao X, Cui T, Lv B, Gao X. · 2026-09-04

open access unreviewed
7
Research progress in metabolic reprogramming and targeting metabolic pathways for clear cell renal cell carcinoma.
Yao JT, Hu PC, Li XW, Xu JC, Wang KJ, Ye SZ, Meng XY, Chen HC, Liang Y, Ma Q. · 2025-12-19

open access unreviewed
8
Ketogenic Diet–Associated Remodeling of the Cortical Proteome in Rats With Genetic Absence Epilepsy
Gunel A, Guler U, Toplu A, Acikgoz N, Onat B, Moniri A, Salih B, Sezerman O, Onat F. · 2026-10-01

open access unreviewed
9
Metabolic effects of periodontal pathogens Fusobacterium nucleatum and Porphyromonas gingivalis in colorectal cancer cells.
Gopinath D, Selvakumar B, Sekar P, Mohammed MM, Li Z. · 2026-09-24

open access unreviewed
10
Propionate promotes CD8+ T-cell infiltration and enhances immunotherapy efficacy in colorectal cancer.
Pan J, Tong L, Fei R, Wu K, Ji J, Sun T, Zhao Y, Zhang J, Feng H, Hua H, Yao HP. · 2026-10-01

open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.