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unreviewed

Mitochondrial thiolase (acetyl-CoA acetyltransferase, T2/ACAT1)

2 reactions · 2 pathways

Cofactors used

CoA-SH · B5 (Pantothenic acid)

What it does, reaction by reaction

2 reactions

Ketogenesis Lipid Metabolism · Liver mitochondrial matrix

step 1 Reversible

2 acetyl-CoA → acetoacetyl-CoA + CoA-SH

Converts Acetyl-CoA into Acetoacetyl-CoA CoA-SH

› Notes

Mitochondrial thiolase (acetyl-CoA acetyltransferase) condenses two acetyl-CoA molecules. This reaction is reversible and is shared conceptually with the terminal thiolysis step of β-oxidation.

Ketolysis (Ketone Body Utilization) Lipid Metabolism · Mitochondrial matrix

step 3 Irreversible/directional

Acetoacetyl-CoA + CoA-SH → 2 acetyl-CoA

Converts Acetoacetyl-CoA CoA-SH into Acetyl-CoA

› Notes

Mitochondrial thiolase cleaves acetoacetyl-CoA. The two acetyl-CoA molecules then enter the TCA cycle.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    The Crimean-Congo haemorrhagic fever virus hijacks the liver lipid metabolic pathway for virion production.

    Gautam A, Zhong L, Ogire E, Bodoirat S, Riedmiller I, Sander WJ, Boson B, Gandhi A, Burlaud-Gaillard J, Amira… · 2026-03-30

    open access unreviewed
  2. 2
    Gut microbiota metabolic reprogramming drives the development of metabolic diseases in the host.

    Wang Y, Huang B, Wei X, Guan Y, Li L, Zheng Y, Sun W. · 2026-03-14

    cited 10× open access unreviewed
  3. 3
    Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidation.

    Wang W, Gao Y, Chen Y, Cheng M, Wei L, Sang Y, Zhang L, Dai R, Wang Y. · 2026-03-10

    open access unreviewed
  4. 4
    The multifaceted landscape of T cell exhaustion in organ transplantation: From molecular mechanisms (epigenetics, transcription, metabolism) to induction strategies.

    Wang Y, Wu Y, Shen Y, Chen Y, Zhao Y, Zeng X, He K. · 2025-12-06

    open access unreviewed
  5. 5
    Early atherogenesis: In search of etiology.

    Brown PA. · 2026-05-07

    open access unreviewed
  6. 6
    Revealing the transcriptional profile of fish muscle cells in vitro and in vivo: Insights to improve fish muscle culture.

    Zanella BTT, Perez ÉS, Dos Santos Barbosa MF, Valente JS, Duran BOS, Dal-Pai-Silva M. · 2026-03-10

    unreviewed
  7. 7
    A Bioorthogonal Ratiometric Fluorescence Nanoprobe for Imaging the Regulation of O-GlcNAcylation in Atherosclerosis.

    Xu J, Zhang W, Li P, Tang Y, Zhang W, Wang H, Tang B. · 2026-08-13

    unreviewed
  8. 8
    Cholesterol Drives IFITM3<sup>+</sup> Microglia Activation and Induces STING Mediated Neuroinflammation After Ischemic Stroke.

    Cheng Y, Zhou Y, Chen Y, Shen T, Li Y, Chen C, Fan Q, Qi J, Li P, Zhang Y. · 2026-08-01

    unreviewed
  9. 9
    Endogenous metabolite signaling orchestrates tumor immune evasion.

    Liu X, Jiang C, Li Y. · 2026-05-20

    open access unreviewed
  10. 10
    Crotonylation of ACAT1 K181 contributes to radioresistance by impacting lactate metabolism.

    Chen S, Li S, Guo H, Gao S, Gao Y, Ding L, Zhao B, Zhong K, Guan H, Peng RY, Zhou PK. · 2026-07-23

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.